Genome-Wide Association Studies Combined with Genomic Selection as a Tool to Increase Fusarium Head Blight Resistance in Wheat

Verges, Virginia L.; Brown‐Guedira, Gina; Sanford, David A. Van

doi:10.20900/cbgg20210007

Cited by 5 publications

(5 citation statements)

References 60 publications

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“…GWAS is a useful technique to identify significant markers for characteristics in wheat ( Verges et al., 2021 ). GWASs have been reported against the most threatening fungal diseases to wheat production, including rust, smut, and bunt diseases ( Goutam et al., 2015 ).…”

Section: Genome Wide Association Studies For Disease-resistance In Wheatmentioning

confidence: 99%

“…Leaf (Dababat et al, 2016) resistance (Lr) genes have been reported to be linked with a wide range of markers (Imbaby et al, 2014). GWAS also reported in fusarium head blight (FHB) (Verges et al, 2021) resistance in winter wheat lines, suggesting that GWAS is the most effective approach for FHB resistance (Savadi et al, 2018). Furthermore, there are sixteen race-specific resistance genes to common bunts from Bt1 to Bt15 that have been reported (Goates, 2012).…”

Section: Genome Wide Association Studies For Disease-resistance In Wheatmentioning

confidence: 99%

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Intelligent reprogramming of wheat for enhancement of fungal and nematode disease resistance using advanced molecular techniques

et al. 2023

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Wheat (Triticum aestivum L.) diseases are major factors responsible for substantial yield losses worldwide, which affect global food security. For a long time, plant breeders have been struggling to improve wheat resistance against major diseases by selection and conventional breeding techniques. Therefore, this review was conducted to shed light on various gaps in the available literature and to reveal the most promising criteria for disease resistance in wheat. However, novel techniques for molecular breeding in the past few decades have been very fruitful for developing broad-spectrum disease resistance and other important traits in wheat. Many types of molecular markers such as SCAR, RAPD, SSR, SSLP, RFLP, SNP, and DArT, etc., have been reported for resistance against wheat pathogens. This article summarizes various insightful molecular markers involved in wheat improvement for resistance to major diseases through diverse breeding programs. Moreover, this review highlights the applications of marker assisted selection (MAS), quantitative trait loci (QTL), genome wide association studies (GWAS) and the CRISPR/Cas-9 system for developing disease resistance against most important wheat diseases. We also reviewed all reported mapped QTLs for bunts, rusts, smuts, and nematode diseases of wheat. Furthermore, we have also proposed how the CRISPR/Cas-9 system and GWAS can assist breeders in the future for the genetic improvement of wheat. If these molecular approaches are used successfully in the future, they can be a significant step toward expanding food production in wheat crops.

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Section: Genome Wide Association Studies For Disease-resistance In Wheatmentioning

confidence: 99%

Section: Genome Wide Association Studies For Disease-resistance In Wheatmentioning

confidence: 99%

Intelligent reprogramming of wheat for enhancement of fungal and nematode disease resistance using advanced molecular techniques

et al. 2023

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“…Historical data sets are a rich resource for genomic selection, as they are frequently comprised of quality data for traits of interest over a range of environments (Boyles et al, 2019), and studies have demonstrated their utility in genomics‐assisted breeding (Dawson et al, 2013; Rutkoski et al, 2015; Sarinelli et al, 2019; Storlie & Charmet, 2013; Verges et al, 2020). Research has examined various strategies for optimizing training populations based on genetic relationships, population size and structure, marker density and significance, heritability, and environment similarity (Berro et al, 2019; Lozada et al, 2019; Norman et al, 2018; Verges et al, 2021). In the SUWWSN, environments were selected for inclusion based on biplot analysis and performance of the resistant and susceptible check varieties in a given location and year.…”

Section: Implementation Of Genomic Selection For Fhb Resistancementioning

confidence: 99%

“…Exploring methods to increase the accuracy of predictions is a continuous, iterative process. Including significant markers as fixed effects in prediction models and selecting markers based on GWAS analysis has achieved some success in improving prediction accuracy (Larkin et al, 2020; Lozada et al, 2019; Verges et al, 2020; Verges et al, 2021). Cluster analysis to select environments for training population construction has also been shown to improve prediction accuracy for FDK and DON (Winn et al, 2023) and provide additional support concerning decisions about including the highest‐quality data.…”

Section: Implementation Of Genomic Selection For Fhb Resistancementioning

confidence: 99%

Approaching 25 years of progress towards Fusarium head blight resistance in southern soft red winter wheat (Triticum aestivum L.)

et al. 2023

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Tremendous progress has been made in variety development and host plant resistance to mitigate the impact of Fusarium head blight (FHB) since the disease manifested in the southeastern United States in the early 2000s. Much of this improvement was made possible through the establishment of and recurring support from the US Wheat & Barley Scab Initiative (USWBSI). Since its inception in 1997, the USWBSI has enabled land‐grant institutions to make advances in reducing the annual threat of devastating FHB epidemics. A coordinated field phenotyping effort for annual germplasm screening has become a staple tool for selection in public and private soft red winter wheat (SRWW) breeding programmes. Dedicated efforts of many SRWW breeders to identify and utilize resistance genes from both native and exotic sources provided a strong foundation for improvement. In recent years, implementation of genomics‐enabled breeding has further accelerated genetic gains in FHB resistance. This article reflects on the improvement of FHB resistance in southern SRWW and contextualizes the monumental progress made by collaborative, persistent, and good old‐fashioned cultivar development.

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“…The associated loci were distributed across all chromosomes except 2D, 6A, 6D and 7D ( Hu et al, 2020 ). In addition, numerous recent studies have used GWAS in FHB resistance ( Verges, Brown-Guedira & Van Sanford, 2021 ; Gaire et al, 2021 ; Ghimire et al, 2022 ; Wu et al, 2019 ). It appears that using GWAS to investigate wheat FHB is a very promising endeavor.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association analysis of type II resistance to Fusarium head blight in common wheat

Wang,

Zhao,

Zhao

et al. 2023

PeerJ

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Background Fusarium head blight (FHB) is a disease affecting wheat spikes caused by some Fusarium species and leads to cases of severe yield reduction and seed contamination. Identifying resistance genes/QTLs from wheat germplasm may help to improve FHB resistance in wheat production. Methods Our study evaluated 205 elite winter wheat cultivars for FHB resistance. A high-density 90K SNP array was used for genotyping the panel. A genome-wide association study (GWAS) from cultivars from three different environments was performed using a mixed linear model (MLM). Results Sixty-six significant marker-trait associations (MTAs) were identified (P < 0.001) on fifteen chromosomes that explained the phenotypic variation ranging from 5.4 to 11.2%. Some important new MTAs in genomic regions involving FHB resistance were found on chromosomes 2A, 3B, 5B, 6A, and 7B. Six MTAs at 92 cM on chromosome 7B were found in cultivars from two different environments. Moreover, there were 11 MTAs consistently associated with diseased spikelet rate and diseased rachis rate as pleiotropic effect loci and D_contig74317_533 on chromosome 5D was novel for FHB resistance. Eight new candidate genes of FHB resistance were predicated in wheat in this study. Three candidate genes, TraesCS5D02G006700, TraesCS6A02G013600, and TraesCS7B02G370700 on chromosome 5DS, 6AS, and 7BL, respectively, were perhaps important in defending against FHB by regulating intramolecular transferase activity, GTP binding, or chitinase activity in wheat, but further validation in needed. In addition, a total of five favorable alleles associated with wheat FHB resistance were discovered. These results provide important genes/loci for enhancing FHB resistance in wheat breeding by marker-assisted selection.

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Genome-Wide Association Studies Combined with Genomic Selection as a Tool to Increase Fusarium Head Blight Resistance in Wheat

Cited by 5 publications

References 60 publications

Intelligent reprogramming of wheat for enhancement of fungal and nematode disease resistance using advanced molecular techniques

Intelligent reprogramming of wheat for enhancement of fungal and nematode disease resistance using advanced molecular techniques

Approaching 25 years of progress towards Fusarium head blight resistance in southern soft red winter wheat (Triticum aestivum L.)

Genome-wide association analysis of type II resistance to Fusarium head blight in common wheat

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