Genome-Wide Association Studies and Runs of Homozygosity to Identify Reproduction-Related Genes in Yorkshire Pig Population

Zhang, Lige; Zhang, Songyuan; Yuan, Meng; Zhan, Fengting; Song, Mingkun; Shang, Peng; Yang, Feng; Li, Xiuling; Qiao, Ruimin; Han, Xuelei; Li, Xinjian; Fang, Meiying; Wang, Kejun

doi:10.3390/genes14122133

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…Thus, studying the genetic regulatory mechanisms of mink growth is crucial for the mink breeding industry. In recent years, with the rapid development of sequencing technology, genomics has been widely used in the study of molecular regulation mechanisms of animal growth and development, promoting the process of animal genome selection breeding [3][4][5][6][7]. However, the relevant research on mink is still lagging behind.…”

Section: Introductionmentioning

confidence: 99%

Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq

Rong,

Xing,

Zhang

2024

Biology

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Mink is a kind of small and precious fur animal resource. In this study, we employed transcriptomics technology to analyze the gene expression profile of mink pectoral muscle tissue, thereby elucidating the regulatory mechanisms underlying mink growth and development. Consequently, a total of 25,954 gene expression profiles were acquired throughout the growth and development stages of mink at 45, 90, and 120 days. Among these profiles, 2607 genes exhibited significant differential expression (|log2(fold change)| ≥ 2 and p_adj < 0.05). GO and KEGG enrichment analyses revealed that the differentially expressed genes were primarily associated with the mitotic cell cycle process, response to growth factors, muscle organ development, and insulin resistance. Furthermore, GSEA enrichment analysis demonstrated a significant enrichment of differentially expressed genes in the p53 signaling pathway at 45 days of age. Subsequent analysis revealed that genes associated with embryonic development (e.g., PEG10, IGF2, NRK), cell cycle regulation (e.g., CDK6, CDC6, CDC27, CCNA2), and the FGF family (e.g., FGF2, FGF6, FGFR2) were all found to be upregulated at 45 days of age in mink, which suggested a potential role for these genes in governing early growth and developmental processes. Conversely, genes associated with skeletal muscle development (PRVA, TNNI1, TNNI2, MYL3, MUSTN1), a negative regulator of the cell cycle gene (CDKN2C), and IGFBP6 were found to be up-regulated at 90 days of age, suggesting their potential involvement in the rapid growth of mink. In summary, our experimental data provide robust support for elucidating the regulatory mechanisms underlying the growth and development of mink.

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Section: Introductionmentioning

confidence: 99%

Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq

Rong,

Xing,

Zhang

2024

Biology

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Application of GWAS and mGWAS in Livestock and Poultry Breeding

Ren,

Gao,

et al. 2024

Animals

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In recent years, genome-wide association studies (GWAS) and metabolome genome-wide association studies (mGWAS) have emerged as crucial methods for investigating complex traits in animals and plants. These have played pivotal roles in research on livestock and poultry breeding, facilitating a deeper understanding of genetic diversity, the relationship between genes, and genetic bases in livestock and poultry. This article provides a review of the applications of GWAS and mGWAS in animal genetic breeding, aiming to offer reference and inspiration for relevant researchers, promote innovation in animal genetic improvement and breeding methods, and contribute to the sustainable development of animal husbandry.

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Genome-Wide Association Studies and Runs of Homozygosity to Identify Reproduction-Related Genes in Yorkshire Pig Population

Cited by 2 publications

References 89 publications

Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq

Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq

Application of GWAS and mGWAS in Livestock and Poultry Breeding

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