Genome-wide association mapping and population structure for stripe rust in Pakistani wheat germplasm

Qaiser, Rizwan; Akram, Zahid; Asad, Shahzad; Haq, Inamul; Malik, Saad Imran; Fayyaz, Muhammad; Sufiyan, Muhammad; Khattak, Sahir Hameed; Sandhu, Karansher S.; Sidhu, Gaganjot

doi:10.30848/pjb2022-4(11)

Cited by 6 publications

(7 citation statements)

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“…To cope with this lethal issue, the use of advanced technology by combining various fields and methodologies is of great benefit, in terms of loss reduction [17,19,[60][61][62][63][64]. In this regard, specifically, it has been demonstrated that a number of classes of antimicrobial nanoparticles (NPs) and nano sized carriers for antibiotic delivery are efficient methods for the treatment of infectious or fatal diseases, including those that are resistant to antibiotics, in vitro as well as in plant or animal models [54,65].…”

Section: Discussionmentioning

confidence: 99%

“…Long-term effective methods with fewer side effects will be needed using a combination methodology (such as marker technology, gene/protein sequencing, docking studies and specially nanotechnology), rather than a short-range approach and a focused conventional strategy/approach [17][18][19]. In this aspect, the developed "Nanotechnology-based" combination therapy decreases toxicity that is linked to a specific drug and suppresses multi-drug resistance because of different mechanisms of action [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant Escherichia coli and Pseudomonas aeruginosa

Yu,

Alkasir,

Farrukh

et al. 2024

Pol. J. Environ. Stud.

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Nanotechnology offers exciting prospects against infectious agents, particularly multidrug resistance bacteria (MDR), which is the roaring concern of this era. Zinc oxide nanoparticles (ZnO-Nps) efficiently deliver therapeutic agents into living systems due to their biocompatibility and bioactivity, which make them highly effective against infectious pathogens. The present investigation was designed to investigate the impact of the ZnO-Nps in combination with the Piperacillin-Tazobactam (TZP) drug against MDR. TZP are beta-lactam antibiotics highly effective against Gram-positive and Gram-negative

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant Escherichia coli and Pseudomonas aeruginosa

Yu,

Alkasir,

Farrukh

et al. 2024

Pol. J. Environ. Stud.

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“…For this purpose, the C. roseus extract was added to the 1 mM AgNO 3 solution, which reduces silver ions into silver particles, as indicated by the change in color from light green to dark brown in the synthesis, which confirmed synthesis of C. AgNPs in this study. The solution’s dark color was exhibited due to the surface plasmon resonance phenomenon [ 47 ]. Earlier studies indicated that the reduction of silver ions and stability of AgNPs are due to the presence of phyto-constituents or plant metabolites [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Biogenic Synthesis of Silver Nanoparticles Using Catharanthus roseus and Its Cytotoxicity Effect on Vero Cell Lines

Jamil¹,

Khattak²,

Farrukh

et al. 2022

Molecules

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Background: Type 2 diabetes mellitus (DM2) is a chronic and sometimes fatal condition which affects people all over the world. Nanotherapeutics have shown tremendous potential to combat chronic diseases—including DM2—as they enhance the overall impact of drugs on biological systems. Greenly synthesized silver nanoparticles (AgNPs) from Catharanthus roseus methanolic extract (C. AgNPs) were examined primarily for their cytotoxic and antidiabetic effects. Methods: Characterization of C. AgNPs was performed by UV–vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and atomic force microscopy (AFM). The C. AgNPs were trialed on Vero cell line and afterwards on an animal model (rats). Results: The C. AgNPs showed standard structural and functional characterization as revealed by FTIR and XRD analyses. The zetapotential analysis indicated stability while EDX analysis confirmed the formation of composite capping with Ag metal. The cytotoxic effect (IC50) of C. AgNPs on Vero cell lines was found to be 568 g/mL. The animal model analyses further revealed a significant difference in water intake, food intake, body weight, urine volume, and urine sugar of tested rats after treatment with aqueous extract of C. AgNPs. Moreover, five groups of rats including control and diabetic groups (NC1, PC2, DG1, DG2, and DG3) were investigated for their blood glucose and glycemic control analysis. Conclusions: The C. AgNPs exhibited positive potential on the Vero cell line as well as on experimental rats. The lipid profile in all the diabetic groups (DG1-3) were significantly increased compared with both of the control groups (p < 0.05). The present study revealed the significance of C. AgNPs in nanotherapeutics.

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“…The discovery of new methods and technology has helped humanity in many ways [ 88 , 89 , 90 , 91 ], and one of the common examples is the KD, which has been successfully used to manage seizures [ 92 ]. The employment of KD for treating neurological disorders, such as epileptic seizures is increasing worldwide.…”

Section: Importance Of Kdmentioning

confidence: 99%

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

et al. 2022

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Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.

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Genome-wide association mapping and population structure for stripe rust in Pakistani wheat germplasm

Cited by 6 publications

References 0 publications

Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant Escherichia coli and Pseudomonas aeruginosa

Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant Escherichia coli and Pseudomonas aeruginosa

Biogenic Synthesis of Silver Nanoparticles Using Catharanthus roseus and Its Cytotoxicity Effect on Vero Cell Lines

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

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