Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets

Beshiri, Michael L.; Islam, Abul B.M.M.K.; DeWaal, Dannielle C.; Richter, W; Love, J. Christopher; López‐Bigas, Núria; Benevolenskaya, Elizaveta V.

doi:10.3791/2101-v

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…JmjN and JmjC are specific demethylase active regions; the mutation of ARID domain affects the enzyme activities of JmjN and JmjC [22]. The PHD domain can specifically identify and bind to H3K4me2/3 [23], is structurally similar to the tail of C5HC2 LXCXE and non-T/E1A, and regulates KDM5A and pRb (retinoblastoma protein) p107 and TATA and other proteins. In summary, KDM5A can regulate various biological activities of cells by coordinating multiple functional domains.…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of KDM5A, KDM5B, and FOXO1 in endometrial cancer

Gao,

Gao

2024

pjp

View full text Add to dashboard Cite

There is growing evidence that the KDM5 family of histone demethylases plays a causal role in human cancer. However, few studies have been reported on the KDM5 family in endometrial carcinoma (EC). Moreover, it was found that there was some correlation between the KDM5 family and FOXO1 in EC. The current study was performed to explore the expressions of KDM5A, KDM5B, and FOXO1 in endometrioid adenocarcinoma detected by immunohistochemistry; paracancer endometrium, simple hyperplastic endometrium, and normal endometrium were used as control groups to explore the possible diagnostic value of KDM5A and KDM5B expression in endometrioid adenocarcinoma, with the aim of evaluating the potential of this marker in predicting the prognosis of endometrioid adenocarcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%