Abstract:LIM‐domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome‐wide level, which are crucial to further understand their functions in cardiac hypertrophy, are currently lacking. Here, 70 LIM genes were identified and characterised in mice. The expression patterns of LIM genes differ greatly during cardiac development and in the case of hypertrophy. Both Crip2 and Xirp2 are differentially expressed in cardiac hypertrophy and durin… Show more
“…In particular, XIRP2 shows differential expression during cardiac hypertrophy and HF. 85 Regarding the extracellular matrix, the levels of non-collagen proteins periostin and biglycan increase over time. Previous studies have shown that β-adrenergic receptor (β-AR) stimulation is the primary mechanism regulating cardiac output.…”
Heart Failure (HF) is the terminal stage of various cardiac diseases, posing a significant threat to human health. Early stages of HF often lack typical symptoms, leading to frequent misdiagnoses....
“…In particular, XIRP2 shows differential expression during cardiac hypertrophy and HF. 85 Regarding the extracellular matrix, the levels of non-collagen proteins periostin and biglycan increase over time. Previous studies have shown that β-adrenergic receptor (β-AR) stimulation is the primary mechanism regulating cardiac output.…”
Heart Failure (HF) is the terminal stage of various cardiac diseases, posing a significant threat to human health. Early stages of HF often lack typical symptoms, leading to frequent misdiagnoses....
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