Genome-Wide Analysis of Facial Regionalization in Zebrafish

Askary, Amjad; Xu, Pengfei; Barske, Lindsey; Bay, Maxwell; Bump, Paul; Balczerski, Bartosz; Ma, Baohua; Crump, J. Gage

doi:10.1101/114801

2017

DOI: 10.1101/114801

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Genome-Wide Analysis of Facial Regionalization in Zebrafish

Amjad Askary

Pengfei Xu

Lindsey Barske

et al.

Abstract: Running Title: Genomic analysis of the face Summary Statement: Using zebrafish to purify distinct groups of embryonic cells, Askary et al. have created a detailed map of how thousands of genes are deployed to shape the developing face.peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/114801 doi: bioRxiv preprint first posted online Mar. We then performed mutational analysis of a number … Show more

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Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations

Endo

Johnson

Morino³

et al. 2018

Sci Rep

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Skin trait variation impacts quality-of-life, especially for females from the viewpoint of beauty. To investigate genetic variation related to these traits, we conducted a GWAS of various skin phenotypes in 11,311 Japanese women and identified associations for age-spots, freckles, double eyelids, straight/curly hair, eyebrow thickness, hairiness, and sweating. In silico annotation with RoadMap Epigenomics epigenetic state maps and colocalization analysis of GWAS and GTEx Project eQTL signals provided information about tissue specificity, candidate causal variants, and functional target genes. Novel signals for skin-spot traits neighboured AKAP1/MSI2 (rs17833789; P = 2.2 × 10−9), BNC2 (rs10810635; P = 2.1 × 10−22), HSPA12A (rs12259842; P = 7.1 × 10−11), PPARGC1B (rs251468; P = 1.3 × 10−21), and RAB11FIP2 (rs10444039; P = 5.6 × 10−21). HSPA12A SNPs were the only protein-coding gene eQTLs identified across skin-spot loci. Double edged eyelid analysis identified that a signal around EMX2 (rs12570134; P = 8.2 × 10−15) was also associated with expression of EMX2 and the antisense-RNA gene EMX2OS in brain putamen basal ganglia tissue. A known hair morphology signal in EDAR was associated with both eyebrow thickness (rs3827760; P = 1.7 × 10−9) and straight/curly hair (rs260643; P = 1.6 × 10−103). Excessive hairiness signals’ top SNPs were also eQTLs for TBX15 (rs984225; P = 1.6 × 10−8), BCL2 (rs7226979; P = 7.3 × 10−11), and GCC2 and LIMS1 (rs6542772; P = 2.2 × 10−9). For excessive sweating, top variants in two signals in chr2:28.82-29.05 Mb (rs56089836; P = 1.7 × 10−11) were eQTLs for either PPP1CB or PLB1, while a top chr16:48.26–48.45 Mb locus SNP was a known ABCC11 missense variant (rs6500380; P = 6.8 × 10−10). In total, we identified twelve loci containing sixteen association signals, of which fifteen were novel. These findings will help dermatologic researchers better understand the genetic underpinnings of skin-related phenotypic variation in human populations.

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Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations

Endo

Johnson

Morino³

et al. 2018

Sci Rep

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Genome-Wide Analysis of Facial Regionalization in Zebrafish

Cited by 1 publication

References 72 publications

Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations

Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations

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