Genome wide analyses reveal the population distinctiveness of the ‘
            <i>Nera del Mela</i>
            ’ sheep

Chessari, Giorgio; Criscione, Andrea; Tolone, Marco; Zumbo, Alessandro; Riggio, Silvia; Rizzuto, Ilaria; Moscarelli, Angelo; Macaluso, Vito; Portolano, Baldassare; Sardina, Maria Teresa; Mastrangelo, Salvatore

doi:10.1080/1828051x.2023.2216724

Cited by 1 publication

(1 citation statement)

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“…Therefore, identifying adapted genetic resources is essential to provide support and guidance in formulating policies to ensure the conservation and sustainable reproduction of this biological heritage. Hence, the sustainable management of farm animal genetic resources is an urgent and complex task to safeguard their significant contribution to the genetic heritage [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Genomic analysis revealed hotspots of genetic adaptation and risk of disappearance in the Brazilian goat populations

Sobrinho,

Coelho,

de Oliveira Moura

et al. 2024

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We accessed a 50K Illumina SNP genotype dataset from two important goat breeds of the Brazilian semi- arid region to analyze the abundance and length of runs of homozygosity (ROH). This analysis aims to elucidate the importance of adaptation history in the genome of the Brazilian goat populations and to measure genomic inbreeding. Heterozygosity-rich regions (HRR) or genome regions of high genetic variability provide clues about how diversity might be associated with increased fitness, avoiding deleterious homozygous alleles. Overall, 22,872 ROH were identified. The average number of ROH per individual ranged from 74.73 (Anglo-Nubian commercial breed) to 173.85 (Marota landrace). Analysis of the distribution of runs of homozygosity according to their size showed that, for both breeds, the majority of ROH were in the short (<2.0 Mb) category (65.6%). ROH-based inbreeding (FROH) revealed low levels in Anglo-Nubian (0.0627) and high levels in Marota (0.1419), likely due to a reduction in effective population size over generations in the Marota landrace. We defined islands of ROH and HRR and identified common regions in the Marota goat, where genes related to various traits such as embryonic development, body growth, lipid homeostasis, and brain functions are located. These results indicate that such regions are associated with many traits and have therefore been under selective pressure in these goat breeds reared for different purposes.

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