Genome-wide analyses of long noncoding RNA expression profiles in lung adenocarcinoma

Zhang, Peng; Wang, Jun; Shan, Bin; Yuan, Fulai; Li, Bin; Dong, Yeping; Peng, Wei; Shi, Weisong; Cheng, Yuanda; Gao, Yang; Zhang, Chunfang; Duan, Chaojun

doi:10.1038/s41598-017-15712-y

Cited by 21 publications

(20 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 Peng et al analyzed aberrant lncRNA genes in LAD and found that the top GO terms are mainly enriched in cell adhesion, parts of the extracellular region, and cytoskeletal protein binding. 29 In our comparison of LAD with and without lymphatic metastasis, we found that cell-cell adhesion was downregulated in BP of GO, and when altered may facilitate the migration and metastasis of tumor cells. Upregulated genes in this comparison were enriched in mostly intracellular rather than extracellular regions where the downregulated genes were found.…”

mentioning

confidence: 75%

See 1 more Smart Citation

Microarray expression profile of long non‐coding RNAs in human lung adenocarcinoma

et al. 2018

View full text Add to dashboard Cite

BackgroundLong non‐coding RNAs (lncRNAs) participate in many biological dynamics and play significant roles in gene regulation. LncRNA expression is altered in many cancers; however, the expressions and functions of lncRNA genes in lung adenocarcinoma (LAD) remain unknown.MethodsLncRNA and messenger RNA (mRNA) expression in LAD without lymphatic metastasis versus paired adjacent non‐tumor (ANT) lung tissues and LAD with versus without lymphatic metastasis were analyzed using Human LncRNA Arraystar V3.0. The expression levels of four downregulated and four upregulated lncRNAs were verified using quantitative real‐time PCR in cells and tissue specimens.ResultsIn this study, 949 lncRNAs and 681 mRNAs had differential expression in LAD without lymphatic metastasis compared to ANT lung tissues, while 2740 lncRNAs and 1714 mRNAs were differentially expressed in LAD with lymphatic metastasis compared to LAD without lymphatic metastasis. The expression patterns of selected lncRNAs (LINC00113, AC005009.1, ARHGAP22‐IT1, AC009411.1, SRGAP3‐AS2, EGFEM1P, FAM66E, and HLA‐F‐AS1) were consistent with microarray data. Differentially expressed mRNA genes were enriched in crucial Gene Ontology terms and pathways.ConclusionOur results revealed differentially expressed lncRNAs in LAD, suggesting lncRNAs may be potential indicators for LAD diagnosis and therapy.

show abstract

mentioning

confidence: 75%

“…Peng et al . analyzed aberrant lncRNA genes in LAD and found that the top GO terms are mainly enriched in cell adhesion, parts of the extracellular region, and cytoskeletal protein binding …”

Section: Discussionmentioning

confidence: 99%

Microarray expression profile of long non‐coding RNAs in human lung adenocarcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…LncNONHSAT081507.1 (LINC81507) was first identified by Peng et al using Agilent Human LncRNA Array. 44 Recently, Peng et al found reduced expression of LINC81507 resulted in cell growth, proliferation, migration and EMT in NSCLC cells, whereas ectopic overexpression of LINC81507 resulted in the opposite effects both in vitro and in vivo. 45 LINC81507 acted as a ceRNA for miR-199b-5p through directly binding and interfering miR-199b-5p-mediated regulation of CAV1 to reduce migration and invasion.…”

Section: Tumour-suppressor Lncrnasmentioning

confidence: 99%

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Fang

Wang

Gong

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs.

show abstract

“…8 Accumulative evidences demonstrated that lncRNA could also act as a sponge for microRNA (miRNA) to suppress the target gene of the miRNA, which is considered to be a competing endogenous RNA (ceRNA). [10][11][12][13] Among the lncRNAs, colon cancer-associated transcript-1 (CCAT1) was proved highly associated with human cancers, 14 including gastric cancer, 15 ovarian cancer, 16 breast cancer, 17 and lung cancer. [10][11][12][13] Among the lncRNAs, colon cancer-associated transcript-1 (CCAT1) was proved highly associated with human cancers, 14 including gastric cancer, 15 ovarian cancer, 16 breast cancer, 17 and lung cancer.…”

Section: Introductionmentioning

confidence: 99%

“…2 Recently, more and more studies indicated that the aberrations of lncRNA expression were found in many types of cancers involving in regulating the cell proliferation and metastasis, which will lead normal cells or tissues to tumorigenesis. [10][11][12][13] Among the lncRNAs, colon cancer-associated transcript-1 (CCAT1) was proved highly associated with human cancers, 14 including gastric cancer, 15 ovarian cancer, 16 breast cancer, 17 and lung cancer. 18 Specifically, lncRNA-CCAT1 has been reported to promote tumorigenesis and development in colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Upregulated LncRNA‐CCAT1 promotes hepatocellular carcinoma progression by functioning as miR‐30c‐2‐3p sponge

Zhang

Cai

Jiang

et al. 2019

Cell Biochemistry & Function

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death over the world. It is well studied that long noncoding RNA colon cancer-associated transcript-1 (CCAT1) played important roles in variety of cancers promoting cell proliferation and metastasis by acting as a competing endogenous RNA (ceRNA) of microRNAs. However, whether CCAT1 could regulate HCC by serving as a ceRNA of microRNA remains to be revealed. In this study, we demonstrated that CCAT1 was highly expressed in HCC tissues and remarkably associated with metastasis. With a bioinformatics prediction and functional assay validation, we found a binding site of miR-30c-2-3p on CCAT1, which was important for CCAT1 to promote cell proliferation. Interestingly, we further revealed a novel recognition site for miR-30c-2-3p on the 3′UTR of CCNE1 by mutative method, luciferase assay, and cell viability confirmation. In general, CCAT1 regulate the expression of CCNE1 by acting as a ceRNA to sponge miR-30c-2-3p in regulating the cell proliferation of HCC. These results suggest that CCAT1 may be a new therapy target for HCC in the future.Significance of the study: Our findings may broaden the understanding of the role of CCAT1 in tumorigenesis and may provide a new therapy target for HCC.

show abstract

Genome-wide analyses of long noncoding RNA expression profiles in lung adenocarcinoma

Cited by 21 publications

References 43 publications

Microarray expression profile of long non‐coding RNAs in human lung adenocarcinoma

Microarray expression profile of long non‐coding RNAs in human lung adenocarcinoma

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Upregulated LncRNA‐CCAT1 promotes hepatocellular carcinoma progression by functioning as miR‐30c‐2‐3p sponge

Contact Info

Product

Resources

About