Genome: twisting stories with DNA

Noguera-Solano, Ricardo; Ruiz-Gutiérrez, Rosaura; Caso, Juan Manuel Rodríguez

doi:10.1016/j.endeavour.2013.05.003

Cited by 11 publications

(6 citation statements)

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“…The designation of complete genetic constitution of an organism as 'genome' was suggested by Hans Winkler in 1920. 4 It was only after a few decades that DNA was demonstrated to be the hereditary material and its three-dimensional structure was illustrated by Watson and Crick model.…”

Section: Genomicsmentioning

confidence: 99%

Omics’ in oral cancer: A comprehensive review

et al. 2022

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Health and disease states are dictated or accompanied by corresponding alterations in genes, mRNAs, proteins and metabolites. Over the past few decades, various ‘omic’ technologies have been developed to study the genome, transcriptome, proteome and metabolome respectively. Since oral cancers are one of the leading causes of death globally, much of research work has attempted to study the analytes in cancerous conditions by utilizing the various ‘omic’ modalities. These studies have aimed to understand the pathogenesis of head and neck cancers, aid in their diagnosis, devise new treatment strategies, and improve prognosis. It is imperative for surgeons and pathologists to be in line with the updates pertaining to various ‘omic’ methodologies available for studying the analytes. The present review comprehensively describes the development of various ‘omic’ technologies, including- genomics, transcriptomics, proteomics and metabolomics, while emphasizing their applicability in oral cancers.

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Section: Genomicsmentioning

confidence: 99%

Omics’ in oral cancer: A comprehensive review

et al. 2022

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“…The concept of “genome” was first proposed in 1920 by Hans Winkler, then professor of Botany at the University of Hamburg, referring to “the haploid number of chromosomes” located in the nucleus [141] . In the current era of biological research, with the technological progress in sequencing and the discovery of the DNA complexity, this concept has been extended to the whole set of DNA sequences in a cell or organism (i.e., accounting for the number of copies of the basic set of chromosomes, or ploidy , and including the DNA material from extranuclear organelles such as the mitochondria).…”

Section: Ai Applications In Functional Genomicsmentioning

confidence: 99%

AI applications in functional genomics

Caudai

Galizia

Geraci

et al. 2021

Computational and Structural Biotechnology Journal

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“…Finding several "yeast genomes" juxtaposed in the yeast sequencing literature is hardly surprising given the multiplicity of definitions other authors have identified for "genomes" more generally (e.g. Keller 2011;Noguera-Solano, Ruiz-Gutierrez, and Rodriguez-Caso 2013). Articulating those genomes and how users mobilized them, however, has consequences for yeast's position in genomics and its continued mobilization in synthetic genomics.…”

Section: Conclusion: the Enduring "Yeast Genome"mentioning

confidence: 99%

Yeast: one cell, one reference sequence, many genomes?

Szymanski

Vermeulen

Wong

2019

New Genetics and Society

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The genome of Saccharomyces cerevisiae-brewer's or baker's yeast-was the first eukaryotic genome to be sequenced in 1996. The identity of that yeast genome has been not just a product of sequencing, but also of its use after sequencing and particularly of its mobilization in scientific literature. We ask "what is the yeast genome?" as an empirical question by investigating "the yeast genome" as a discursive entity. Analyzing publications that followed sequencing points to several "yeast genomes" existing side-by-side: genomes as physical molecules, digital texts, and a historic event. Resolving this unified-yet-multiple "genome" helps make sense of contemporary developments in yeast genomics such as the synthetic yeast project, in which apparently "the same" genome occupies multiple roles and locations, and points to the utility of examining specific nonhuman genomes independent of the Human Genome Project.

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Genome: twisting stories with DNA

Cited by 11 publications

References 0 publications

Omics’ in oral cancer: A comprehensive review

Omics’ in oral cancer: A comprehensive review

AI applications in functional genomics

Yeast: one cell, one reference sequence, many genomes?

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