Genome to gut: crop engineering for human microbiomes

Serrano, Karen; Bezrutcyzk, Margot

doi:10.1038/s41579-022-00850-6

Cited by 1 publication

(1 citation statement)

References 5 publications

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“… 14 , 15 Therefore, it was hypothesized that fruits and vegetables serve as the main direct sources of environmental microbiota 14 , 16 and may modulate the composition and functionality of our gut microbiomes. 17 However, there has been no study to date to investigate the potential transfer of the natural fruit and vegetable microbiota to the human gut. Moreover, fruit and vegetable associated bacteria are likely underrepresented in the human gut because large-scale food microbiome metagenomes are needed.…”

Section: Introductionmentioning

confidence: 99%

The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut

Wicaksono,

Cernava,

Wassermann

et al. 2023

Gut Microbes

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Diversity of the gut microbiota is crucial for human health. However, whether fruit and vegetable associated bacteria contribute to overall gut bacterial diversity is still unknown. We reconstructed metagenome-assembled genomes from 156 fruit and vegetable metagenomes to investigate the prevalence of associated bacteria in 2,426 publicly available gut metagenomes. The microbiomes of fresh fruits and vegetables and the human gut are represented by members in common such as Enterobacterales, Burkholderiales , and Lactobacillales . Exposure to bacteria via fruit and vegetable consumption potentially has a beneficial impact on the functional diversity of gut microbiota particularly due to the presence of putative health-promoting genes for the production of vitamin and short-chain fatty acids. In the human gut, they were consistently present, although at a low abundance, approx. 2.2%. Host age, vegetable consumption frequency, and the diversity of plants consumed were drivers favoring a higher proportion. Overall, these results provide one of the primary links between the human microbiome and the environmental microbiome. This study revealed evidence that fruit and vegetable-derived microbes could be found in the human gut and contribute to gut microbiome diversity.

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