Genome sequencing reveals molecular subgroups in oral epithelial dysplasia
Agustín MÁRQUEZ,
Isidora MUJICA,
Natalia JORDAN
et al.
Abstract:This study aimed to analyze the molecular characteristics of oral epithelial dysplasia (OED), highlighting the pathways and variants of genes that are frequently mutated in oral squamous cell carcinoma (OSCC) and other cancers. Ten archival OED cases were retrieved for retrospective clinicopathological analysis and exome sequencing. Comparative genomic analysis was performed between high-grade dysplasia (HGD) and low-grade dysplasia (LGD), focusing on 57 well-known cancer genes, of which 10 were previously des… Show more
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