Genome Sequences of Bacteriophages UPEC01, UPEC03, UPEC06, and UPEC07 Infecting Avian Pathogenic Escherichia coli

Kazibwe, George; Ndekezi, Christian; Alinaitwe, Ruth; Alafi, Stephen; Nanteza, Ann; Kimuda, Magambo Phillip; Nakavuma, Jesca

doi:10.1128/mra.00811-21

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…The major capture structural protein gp23 genes in the MHS112 and GMS130 genomes all comprise 1560 bp and encode 519 amino acid (aa) residues. Comparing these inferred amino acid sequences of gp23 among phages in the genus Gaprivervirus (such as p479 [6], UPEC01, UPEC07 [30], etc.) and several representative T4-like phages in the Myoviridae family, including those infecting the genus Yersinia T4-like phages (such as YpsP-PST [11], fPS-2, fPS-65, fPS-90 [17], fD1 [18], JC221 [19], etc.).…”

Section: Phylogenetic Relationship Analysis Of Phages In the Genus Ga...mentioning

confidence: 99%

Two Novel Yersinia pestis Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci

Jin

Zhong

Wang

et al. 2022

Viruses

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Bacteriophages (phages) have been successfully used as disinfectors to kill bacteria in food and the environment and have been used medically for curing human diseases. The objective of this research was to elucidate the morphological and genomic characteristics of two novel Yersinia pestis phages, vB_YpeM_ MHS112 (MHS112) and vB_YpeM_GMS130 (GMS130), belonging to the genus Gaprivervirus, subfamily Tevenvirinae, family Myoviridae. Genome sequencing showed that the sizes of MHS112 and GMS130 were 170507 and 168552 bp, respectively. A total of 303 and 292 open reading frames with 2 tRNA and 3 tRNA were predicted in MHS112 and GMS130, respectively. The phylogenetic relationships were analysed among the two novel Y. pestis phages, phages in the genus Gaprivervirus, and several T4-like phages infecting the Yersinia genus. The bacteriophage MHS112 and GMS130 exhibited a wider lytic host spectrum and exhibited comparative temperature and pH stability. Such features signify that these phages do not need to rely on Y. pestis as their host bacteria in the ecological environment, while they could be based on more massive Enterobacteriales species to propagate and form ecological barriers against Y. pestis pathogens colonised in plague foci. Such characteristics indicated that the two phages have potential as biocontrol agents for eliminating the endemics of animal plague in natural plague foci.

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Section: Phylogenetic Relationship Analysis Of Phages In the Genus Ga...mentioning

confidence: 99%

Two Novel Yersinia pestis Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci

Jin

Zhong

Wang

et al. 2022

Viruses

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A Brief History of Phage Research and Teaching in Africa

Nagel¹,

Mutai

Josephs

et al. 2022

PHAGE

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Genome Sequences of Bacteriophages UPEC01, UPEC03, UPEC06, and UPEC07 Infecting Avian Pathogenic Escherichia coli

Abstract: Here, we present the genome sequences of four bacteriophages that infect avian pathogenic Escherichia coli . The phages were isolated from raw sewage in Kampala, Uganda. The genome sizes of the phages ranged between 143,140 bp and 178,307 bp, with an average G+C content of 41.25%.

Cited by 2 publications

References 9 publications

Two Novel Yersinia pestis Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci

Two Novel Yersinia pestis Bacteriophages with a Broad Host Range: Potential as Biocontrol Agents in Plague Natural Foci

A Brief History of Phage Research and Teaching in Africa

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