Genome Sequence of Saccharopolyspora erythraea D, a Hyperproducer of Erythromycin

Abstract

Saccharopolyspora erythraea is a Gram-positive bacterium that can produce antibiotics. However, this microorganism must often be genetically improved for higher production before it can be used in an industrial setting. Here, we report the whole-genome sequence of the industrial hyperproducer strong mutator Saccharopolyspora erythraea strain D.

Recently published Streptomyces genome sequences

“…The availability of cheap sequencing has led to the generation of numerous genome sequences for Streptomyces and related species [e.g. (Liu et al ., 2013 )] with the objective of discovering novel metabolic products. However, sequencing the genome and discovering novel gene clusters is just the beginning; many of the metabolic products of these gene clusters are ‘cryptic’, not being expressed under normal laboratory conditions.…”

Complete genome sequence, metabolic model construction, and huangjiu application of Saccharopolyspora rosea A22, a thermophilic, high amylase and glucoamylase actinomycetes

“…There are eight genes associated with ectoine synthesis, with ectoine synthase being the key gene for ectoine synthesis ( Figure 4B ), and the ectA , ectB , ectC , and ectD genes associated with ectoine synthesis and catabolism ( Supplementary Table S8 ). In addition, terpene synthase key gene cyc 2 present in cluster 6 ( Figure 4C and Supplementary Table S8 ), showed 100% similarity to the gene cluster that produces geosmin from Saccharopolyspora erythraea ( Liu et al, 2013 ), indicating that S. rosea A22 has the potential to produce geosmin.…”

Epilithic Biofilms in Lake Baikal: Screening and Diversity of PKS and NRPS Genes in the Genomes of Heterotrophic Bacteria

“…7A, has genes with high homology to erythronolide synthase responsible for the biosynthesis of macrolide 6-desoxy-erythronolide B, which is the precursor of the well-studied and widely known antibiotic erythromycin. It was first isolated in 1949 from the culture liquid of a Saccha ropolyspora erythraea strain (Liu et al 2013). The effect of this antibiotic is due to binding to the 50S ribosome subunit, which disrupts the formation of peptide links between amino acid molecules and blocks peptide synthesis in microorganisms.…”