Genome Sequence of
            <i>Paracoccus</i>
            sp. JM45, a Bacterial Strain Isolated from a Marine Sponge with a Dual Quorum Sensing Inhibition Activity

Gutiérrez‐Barranquero, José A.; Parages, María L.; Dobson, Alan D. W.; Reen, F. Jerry; O’Gara, Fergal

doi:10.1128/mra.01496-18

Cited by 4 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gutiérrez-Barranquero et al found a gene encoding penicillin amidase enzyme (with potential for AHL degradation) in Paracoccus sp. from a marine sponge harvested off the west coast of Ireland [92]. Kalia et al found through genome analysis that three strains belonging to marine gammaproteobacteria possess conserved domains for AHL-lactonases and acylases [93].…”

Section: Quorum Quenching Enzymes Derived From Marine Bacteriamentioning

confidence: 99%

Widespread Existence of Quorum Sensing Inhibitors in Marine Bacteria: Potential Drugs to Combat Pathogens with Novel Strategies

Zhao

Hou

et al. 2019

Marine Drugs

View full text Add to dashboard Cite

Quorum sensing (QS) is a phenomenon of intercellular communication discovered mainly in bacteria. A QS system consisting of QS signal molecules and regulatory protein components could control physiological behaviors and virulence gene expression of bacterial pathogens. Therefore, QS inhibition could be a novel strategy to combat pathogens and related diseases. QS inhibitors (QSIs), mainly categorized into small chemical molecules and quorum quenching enzymes, could be extracted from diverse sources in marine environment and terrestrial environment. With the focus on the exploitation of marine resources in recent years, more and more QSIs from the marine environment have been investigated. In this article, we present a comprehensive review of QSIs from marine bacteria. Firstly, screening work of marine bacteria with potential QSIs was concluded and these marine bacteria were classified. Afterwards, two categories of marine bacteria-derived QSIs were summarized from the aspects of sources, structures, QS inhibition mechanisms, environmental tolerance, effects/applications, etc. Next, structural modification of natural small molecule QSIs for future drug development was discussed. Finally, potential applications of QSIs from marine bacteria in human healthcare, aquaculture, crop cultivation, etc. were elucidated, indicating promising and extensive application perspectives of QS disruption as a novel antimicrobial strategy.

show abstract

Section: Quorum Quenching Enzymes Derived From Marine Bacteriamentioning

confidence: 99%