Genome Sequence of Helicobacter bizzozeroniiStrain CIII-1, an Isolate from Human Gastric Mucosa

Schott, Thomas; Rossi, Mirko; Hänninen, Marja‐Liisa

doi:10.1128/jb.05439-11

Cited by 18 publications

(19 citation statements)

References 11 publications

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“…Therefore, methods that allow bacterial identification at a species level are necessary to better clarify the prevalence of the infection in humans. Access to the full bacterial genome sequences together with the availability of in- Vermoote et al [83] Arnold et al [80] Schott et al [81] Smet et al [82] 1 Two members of the cag pathogenicity island (cag23/E and cagX) were identified in the H. suis genomes. CDSs: Coding sequences.…”

Section: Resultsmentioning

confidence: 99%

“…The complete genomes of 4 of the 5 human-infecting H. heilmannii s.l. have now been published [80][81][82][83] ( Table 2). The sequencing of these genomes showed that H. suis, H. felis, H. bizzozeronii, and H. heilmannii s.s. share many homologues to genes associated with colonization and virulence properties of H. pylori and of other bacteria [80][81][82][83] .…”

Section: Complete Genomes Of H Suis H Felis H Bizzozeronii and mentioning

confidence: 99%

“…have now been published [80][81][82][83] ( Table 2). The sequencing of these genomes showed that H. suis, H. felis, H. bizzozeronii, and H. heilmannii s.s. share many homologues to genes associated with colonization and virulence properties of H. pylori and of other bacteria [80][81][82][83] . These include the urease gene cluster, encoding a key enzyme to bacterial survival in the acidic gastric environment [6] , the neutrophil-activating protein NapA, the γ-glutamyl transpeptidase, as well as complete or almost complete comB secretion system, required for DNA uptake by natural transformation [84] .…”

Section: Complete Genomes Of H Suis H Felis H Bizzozeronii and mentioning

confidence: 99%

“…The H. suis genome is an exception, since it contains a vacA homologue [83] . The dissimilarities between the genomes of H. heilmannii s.l species and the H. pylori genome, including the lack of homologues to wellknown H. pylori virulence factors associated with disease, may partially explain some of the differences between H. pylori and H. heilmannii s.l.-associated pathology [80][81][82][83] . Comparative genome analysis also provided a putative molecular basis for the zoonotic nature of H. heilmannii s.l species [85] .…”

Section: Complete Genomes Of H Suis H Felis H Bizzozeronii and mentioning

confidence: 99%

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Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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Section: Resultsmentioning

confidence: 99%

Section: Complete Genomes Of H Suis H Felis H Bizzozeronii and mentioning

confidence: 99%

Section: Complete Genomes Of H Suis H Felis H Bizzozeronii and mentioning

confidence: 99%

Section: Complete Genomes Of H Suis H Felis H Bizzozeronii and mentioning

confidence: 99%

See 2 more Smart Citations

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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“…The genome of Helicobacter bizzozeronii strain CIII-1, isolated from a 45-year-old female patient with severe gastric symptoms, was sequenced and annotated [20]. The draft genome of another H. bizzozeronii strain (CCUG 35545 T ) was also subsequently sequenced [21].…”

Section: Comparative Genomic and Molecular Biologymentioning

confidence: 99%

Helicobacter spp. Other than H. pylori

Rossi

Hänninen

2012

Helicobacter

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Significant advances have been made over the last 12 months in the understanding of the biology of non-H. pylori Helicobacter species (NHPH). Several studies have investigated the association between NHPH and human disease, including Crohn's disease, lithiasis, liver disease, coronary disease, gastritis, and pyoderma gangrenosum-like ulcers. Novel Helicobacter taxa were identified in new vertebrate hosts, and new methodologies in the fields of identification of Helicobacter spp. and evaluation of antibiotic resistance were described. The genome of the first human-derived gastric NHPH strain (Helicobacter bizzozeronii CIII-1) was sequenced, and several studies elucidated functions of different genes in NHPH. A number of important investigations regarding pathogenesis and immunopathobiology of NHPH infections have been published including the description of a new urease in Helicobacter mustelae. Finally, the effects of the gut microbiota and probiotics on NHPH infections were investigated.

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