Genome Sequence of a Helicobacter pylori Strain Isolated from a Mexican Patient with Intestinal Gastric Cancer

Abstract

Helicobacter pylori strains are the major risk factor for gastric cancer. Strains vary in their content of disease-associated genes, so genome-wide analysis of cancer-isolated strains will help elucidate their pathogenesis and genetic diversity. We present the draft genome sequence of H. pylori isolated from a Mexican patient with intestinal gastric cancer.

Complete Genome Sequence of Helicobacter pylori Strain 7C Isolated from a Mexican Patient with Chronic Gastritis

“…Helicobacter pylori infection produces chronic gastritis and increases the risk of peptic ulcer, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma due to the bacterial interaction between its virulence factors and the cellular components of the host ( 1 , 2 ). Whether the genome structure of the H. pylori strains isolated in Mexico is similar to that of the strains isolated worldwide or not remains unknown, as only one genome of H. pylori isolated in Mexico has been sequenced ( 3 ).…”

Avaliação da densidade de linfócitos T CD8+ em gastrites e adenocarcinomas gástricos de pacientes portadores ou não de infecção pelo Helicobacter pylori

“…Pacientes com H. pylori positivo apresentaram risco 10 vezes maior de desenvolverem algum grau de lesão da mucosa gástrica do que aqueles com ausência . Segundo Méndez-Tenorio et al (2014), essa bactéria está presente em 95% dos casos de gastrite ativa moderada, localizada no antro e em 65% dos casos de GIA. Conforme Nogueira et al (2001), existem bacilos em situações de gastrite inativa, assim como na mucosa normal.…”