Genome Sequence for “Candidatus Mycoplasma haemominutum,” a Low-Pathogenicity Hemoplasma Species

Barker, Emi; Darby, Alistair C.; Helps, Christopher R; Peters, Iain R.; Hughes, Margaret; Radford, Alan; Novacco, Marilisa; Boretti, Felicitas S; Hofmann‐Lehmann, Regina; Tasker, Séverine

doi:10.1128/jb.06560-11

Cited by 12 publications

(5 citation statements)

References 17 publications

(12 reference statements)

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“…The complete singular circular chromosome of M. haemocanis strain Illinois has a size of 919 992 base pairs (bp) and G + C content of 35%; these genomic features are similar to other hemoplasmas species sequenced to date [ 23 , 24 , 26 , 27 ] and within the range reported for other members of the genus Mycoplasma (Table 1 ). As described for all sequenced mycoplasmas (24 species to date), M. haemocanis also uses the opal stop codon (UGA) for tryptophan.…”

Section: Resultssupporting

confidence: 61%

“…Based on the metabolic pathway predictions and specific metabolic deficiencies, a more comprehensive medium can be designed [ 33 ]. To date, only three other species of hemoplasmas have been entirely sequenced [ 23 - 27 ]. The genome features of M. haemocanis , including its small size, low G + C content and use of UGA codon to encode tryptophan, are similar to those of other hemoplasmas and are typical of members of the genus Mycoplasma .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, three species of hemoplasmas, including M. haemofelis , had their genomes completely sequenced and annotated [ 23 - 27 ]. The aim of this study was to sequence the whole genome of M. haemocanis in order to better understand its biology and to perform a complete genomic comparison with its counterpart, M. haemofelis .…”

Section: Introductionmentioning

confidence: 99%

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Mycoplasma haemocanis – the canine hemoplasma and its feline counterpart in the genomic era

Nascimento

Santos

Guimarães

et al. 2012

Vet Res

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Mycoplasma haemocanis is a hemotrophic mycoplasma (hemoplasma), blood pathogen that may cause acute disease in immunosuppressed or splenectomized dogs. The genome of the strain Illinois, isolated from blood of a naturally infected dog, has been entirely sequenced and annotated to gain a better understanding of the biology of M. haemocanis. Its single circular chromosome has 919 992 bp and a low G + C content (35%), representing a typical mycoplasmal genome. A gene-by-gene comparison against its feline counterpart, M. haemofelis, reveals a very similar composition and architecture with most of the genes having conserved synteny extending over their entire chromosomes and differing only by a small set of unique protein coding sequences. As in M. haemofelis, M. haemocanis metabolic pathways are reduced and apparently rely heavily on the nutrients afforded by its host environment. The presence of a major percentage of its genome dedicated to paralogous genes (63.7%) suggests that this bacterium might use antigenic variation as a mechanism to evade the host’s immune system as also observed in M. haemofelis genome. Phylogenomic comparisons based on average nucleotide identity (ANI) and tetranucleotide signature suggest that these two pathogens are different species of mycoplasmas, with M. haemocanis infecting dogs and M. haemofelis infecting cats.

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Section: Resultssupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

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Mycoplasma haemocanis – the canine hemoplasma and its feline counterpart in the genomic era

Nascimento

Santos

Guimarães

et al. 2012

Vet Res

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“…Interestingly, in contrast to most of the other parasites/pathogens, which are characterized by low and persistent infection dynamics, some species of haemoplasmas including MHLB (a) are persistent in all individuals and (b) are horizontally transmitted; additionally, there is (c) no indication that they may convert to disease‐causing states (as for Ca . M. haemominutum , Barker et al., ; Tasker et al., ; Willi et al., ). Future experiments should thus reveal the mechanisms of persistent haemoplasma infection.…”

Section: Discussionmentioning

confidence: 99%

Haemoplasmas in wild rodents: Routes of transmission and infection dynamics

et al. 2018

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The way that some parasites and pathogens persist in the hostile environment of their host for long periods remains to be resolved. Here, longitudinal field surveys were combined with laboratory experiments to investigate the routes of transmission and infection dynamics of such a pathogen-a wild rodent haemotropic bacterium, specifically a Mycoplasma haemomuris-like bacterium. Fleaborne transmission, direct rodent-to-rodent transmission and vertical transmission from fleas or rodents to their offspring were experimentally quantified, and indications were found that the main route of bacterial transmission is direct, although its rate of successful transmission is low (~20%). The bacterium's temporal dynamics was then compared in the field to that observed under a controlled infection experiment in field-infected and laboratory-infected rodents, and indications were found, under all conditions, that the bacterium reached its peak infection level after 25-45 days and then decreased to low bacterial loads, which persist for the rodent's lifetime. These findings suggest that the bacterium relies on persistency with low bacterial loads for long-term coexistence with its rodent host, having both conceptual and applied implications.

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“…Stenotrophomonas maltophilia RR-10, sequence accession AGRB00000000 [42] Strain HIMB30, sequence accession AGIG00000000 [43] Taylorella equigenitalis, sequence accession CP003059 [44] Vibrio campbellii DS40M4, sequence accession AGIE00000000 [45] Vibrio fischeri SR5, sequence accession AHIH00000000 [46] Yersinia enterocolitica, sequence accession AGQO00000000 [47] Phylum Tenericutes Candidatus Mycoplasma haemominutum, sequence accession HE613254 [48] Mycoplasma haemocanis strain Illinois, sequence accession CP003199 [49] Mycoplasma iowae, sequence accession AGFP00000000 [50] Mycoplasma pneumoniae Type 2a Strain 309, sequence accession AP012303 [51] …”

mentioning

confidence: 99%

Genome sequences published outside of Standards in Genomic Sciences, January-March 2012

Nelson

2012

Stand. Genomic Sci.

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Genome Sequence for “Candidatus Mycoplasma haemominutum,” a Low-Pathogenicity Hemoplasma Species

Abstract: We present the genome sequence of "Candidatus Mycoplasma haemominutum" strain Birmingham 1, a low-pathogenicity feline hemoplasma strain.

Cited by 12 publications

References 17 publications

Mycoplasma haemocanis – the canine hemoplasma and its feline counterpart in the genomic era

Mycoplasma haemocanis – the canine hemoplasma and its feline counterpart in the genomic era

Haemoplasmas in wild rodents: Routes of transmission and infection dynamics

Genome sequences published outside of Standards in Genomic Sciences, January-March 2012

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