Genome Sequence Data of <i>Achromobacter vitis</i>, an Endophytic Species with Biocontrol Properties Against <i>Xylella fastidiosa</i>

Ashworth, Vanessa E. T. M.; DiSalvo, Biagio; Vieira, Flávia Campos; Roper, M. Caroline; Rolshausen, Philippe E.

doi:10.1094/mpmi-08-22-0169-a

Cited by 2 publications

(2 citation statements)

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“…Previous studies have demonstrated the biocontrol efficacy of A. xylosoxidans against various plant pathogens, , however, the underlying mechanisms of its antifungal activity remain largely unexplored. In this study, metabolomics analysis revealed that ZAS significantly impacted metabolites associated with cell wall and membrane biosynthesis, including chitin, glucan, trehalose, and ergosterol (Figure D,E).…”

Section: Discussionmentioning

confidence: 99%

“…Achromobacter xylosoxidans, a versatile Gram-negative bacterium found in various ecological niches, including the rhizosphere, has shown potential as a biocontrol agent against various plant pathogens such as Fusarium solani, and Xylella fastidiosa, and the nematode Heterodera filipjevi . The biocontrol mechanisms of Achromobacter are multifaceted, involving iron competition, induction of systemic resistance, and the production of chitinases, which degrade the cell walls of plant pathogens .…”

Section: Introductionmentioning

confidence: 99%

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Peanut Rhizosphere Achromobacter xylosoxidans Inhibits Aspergillus flavus Development and Aflatoxin Synthesis by Inducing Apoptosis through Targeting the Cell Membrane

Sun,

Wang,

Niu

et al. 2024

J. Agric. Food Chem.

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Contamination of crop seeds and feed with Aspergillus flavus and its associated aflatoxins presents a significant threat to human and animal health due to their hepatotoxic and carcinogenic properties. To address this challenge, researchers have screened for potential biological control agents in peanut soil and pods. This study identified a promising candidate, a strain of the nonpigmented bacterium, Achromobacter xylosoxidans ZJS2-1, isolated from the peanut rhizosphere in Zhejiang Province, China, exhibiting notable antifungal and antiaflatoxin activities. Further investigations demonstrated that ZJS2-1 active substances (ZAS) effectively inhibited growth at a MIC of 60 μL/mL and nearly suppressed AFB1 production by 99%. Metabolomic analysis revealed that ZAS significantly affected metabolites involved in cell wall and membrane biosynthesis, leading to compromised cellular integrity and induced apoptosis in A. flavus through the release of cytochrome c. Notably, ZAS targeted SrbA, a key transcription factor involved in ergosterol biosynthesis and cell membrane integrity, highlighting its crucial role in ZJS2-1's biocontrol mechanism. Moreover, infection of crop seeds and plant wilt caused by A. flavus can be efficiently alleviated by ZAS. Additionally, ZJS2-1 and ZAS demonstrated significant inhibitory effects on various Aspergillus species, with inhibition rates ranging from 80 to 99%. These findings highlight the potential of ZJS2-1 as a biocontrol agent against Aspergillus species, offering a promising solution to enhance food safety and protect human health.

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