“…Since the first reconstruction in 2005 ( Borodina et al., 2005 ) five GEMs have been published ( Alam et al., 2010 ; Amara et al., 2018 ; Kim et al., 2014 ; Kumelj et al., 2019 ; Wang et al., 2018 ), including three in 2018: iKS1317 ( Kumelj et al., 2019 ), Sco4 ( Wang et al., 2018 ), and iAA1259 ( Amara et al., 2018 ). In addition, as a model organism for the Actinomycetes, the GEMs of S. coelicolor are frequently used as template for model development of closely related strains ( Mohite et al., 2019 ), such as Streptomyces clavuligerus ( Toro et al., 2018 ), Saccharopolyspora erythraea ( Licona-Cassani et al., 2012 ) and Streptomyces lividans ( Valverde et al., 2018 ). The recent updates of the S. coelicolor GEM were developed in parallel by different research groups: although all groups share the common interest of utilizing a high-quality model for predictions and data analysis, the prevailing approach of independent parallel development is inefficient.…”