Genome-scale metabolic network models for industrial microorganisms metabolic engineering: Current advances and future prospects

Gong, Zhijin; Chen, Jiayao; Jiao, Xinyu; Gong, Hao; Pan, Danzi; Liu, Lingli; Zhang, Yang; Tan, Tianwei

doi:10.1016/j.biotechadv.2024.108319

Biotechnology Advances

2024

DOI: 10.1016/j.biotechadv.2024.108319

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Genome-scale metabolic network models for industrial microorganisms metabolic engineering: Current advances and future prospects

Zhijin Gong,

Jiayao Chen,

Xinyu Jiao

et al.

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2024

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Cited by 5 publications

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Advances in metabolic engineering for enhanced acetyl-CoA availability in yeast

Sha,

Ge,

et al. 2024

Critical Reviews in Biotechnology

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Advances in metabolic engineering for enhanced acetyl-CoA availability in yeast

Sha,

Ge,

et al. 2024

Critical Reviews in Biotechnology

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Strategies for improving fengycin production: a review

Yin,

Wang,

Zhang

et al. 2024

Microb Cell Fact

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Fengycin is an important member of the lipopeptide family with a wide range of applications in the agricultural, food, medical and cosmetic industries. However, its commercial application is severely hindered by low productivity and high cost. Therefore, numerous studies have been devoted to improving the production of fengycin. We summarize these studies in this review with the aim of providing a reference and guidance for future researchers. This review begins with an overview of the synthesis mechanism of fengycin via the non-ribosomal peptide synthetases (NRPS), and then delves into the strategies for improving the fengycin production in recent years. These strategies mainly include fermentation optimization and metabolic engineering, and the metabolic engineering encompasses enhancement of precursor supply, application of regulatory factors, promoter engineering, and application of genome-engineering (genome shuffling and genome-scale metabolic network model). Finally, we conclude this review with a prospect of fengycin production.

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Biochemical and Biorefinery Platform for Second-Generation Bioethanol: Fermentative Strategies and Microorganisms

González-Gloria,

Tomás-Pejó,

Amaya-Delgado

et al. 2024

Fermentation

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Bioethanol is the most commonly used biofuel. It is an alternative to replace fossil fuels in renewable energy; it can be produced from lignocellulosic feedstock using a biotechnological process. Their participation of microorganisms is crucial in the bioconversion process of fermentation for ethanol production and can involve bacteria, fungi, and yeasts. However, when working within bioethanol processes from lignocellulose feedstock, microorganisms face some challenges, such as high temperature, high solids content, and the ability to ferment sugars for high ethanol concentration. Such challenges will depend on operative strategies, such as simultaneous saccharification and fermentation, separate hydrolysis and fermentation, semi-simultaneous saccharification and fermentation, and consolidated bioprocessing; these are the most common configurations. This review presents different trends of the microbial role, biochemical application, and fermentation operative strategies for bioethanol production of the second generation.

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Genome-scale metabolic network models for industrial microorganisms metabolic engineering: Current advances and future prospects

Cited by 5 publications

References 192 publications

Advances in metabolic engineering for enhanced acetyl-CoA availability in yeast

Advances in metabolic engineering for enhanced acetyl-CoA availability in yeast

Strategies for improving fengycin production: a review

Biochemical and Biorefinery Platform for Second-Generation Bioethanol: Fermentative Strategies and Microorganisms

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