Genome-nanosurface interaction of titania nanotube arrays: evaluation of telomere, telomerase and NF-κB activities on an epithelial cell model

Abstract

Schematic illustrations described the activation of pro-survival and cellular senescence activities via NF-κb inhibition upon the interaction from cells grown on TNA nanosurfaces.

Telomerase: a nexus between cancer nanotherapy and circadian rhythm

“…This interaction prompts an increase in the expression of cell cycle regulatory protein-P95 (NBN) and telomeric repeat binding factor 2-interacting protein (TERF21P) within the cell, disrupting the NF-kB pathway and causing cancer cells to undergo senescence. 68 3.2.4 Uses of MnO 2 nanoparticles. In this method, a DNAzyme labeled with the photosensitizer chlorine-e6 (Ce6) is hybridized with a blocker strand labeled with a quencher.…”

“…This interaction prompts an increase in the expression of cell cycle regulatory protein-P95 (NBN) and telomeric repeat binding factor 2-interacting protein (TERF21P) within the cell, disrupting the NF-kB pathway and causing cancer cells to undergo senescence. 68…”

“…For example, TNAs have been observed to stabilize telomeric GQ structures, while CNTs have been found to inhibit telomerase activity by upregulating NBN and TERF21P. 68,72 On the other hand, nanocarriers are used in targeted drug delivery for cancer. Along with the conventional natural and synthetic telomerase inhibitors, many drugs, like helenalin, DOX, curcumin, metformin, chrysin, etc ., are carried by different nano-platforms to suppress telomerase action.…”