“…Genome mining of Bipolaris sorokiniana ND90Pr has revealed a three-enzyme cassette that produces the important fungal sesquiterpenoids sativene 20 and prehelminthosporol 21 . 19 The enzyme SatA, a sativene synthase was shown to cyclise farnesyl diphosphate to give 20 , while the cytochrome P450 enzyme, SatB and reductase SatC convert this to 21 , via C14,C15 dihydroxylations, ring cleavage, aldehyde reduction and hemiacetal ring closure. Genome sequencing, terpenoid metabolomics and bioinformatics have been used to characterise ten novel type I terpene synthases from red algae such as Laurencia subopposita , which produces the halogenated terpenoid oppositol 22 .…”