2016
DOI: 10.1002/ece3.2395
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Genome methylation patterns across castes and generations in a parasitoid wasp

Abstract: Environmental influences shape phenotypes within and across generations, often through DNA methylations that modify gene expression. Methylations were proposed to mediate caste and task allocation in some eusocial insects, but how an insect's environment affects DNA methylation in its offspring is yet unknown. We characterized parental effects on methylation profiles in the polyembryonic parasitoid wasp Copidosoma koehleri, as well as methylation patterns associated with its simple caste system. We used methyl… Show more

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Cited by 10 publications
(6 citation statements)
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“…While MS‐AFLP proved an adequate technique to investigate DNA methylation changes in post‐hatch zebra finches, the technique is limited in its ability to provide information about the sequence and function of methylated loci (Fulneček and Kovařík ). Consequently, correlations between the methylation patterns observed in our study, and their phenotypic effects are yet to be elucidated (Shaham et al ). It would be useful for future work to focus on next‐generation sequence‐based techniques, such as bisulfite sequencing (Bentz et al , Lea et al , Weyrich et al ).…”
Section: Discussionmentioning
confidence: 84%
“…While MS‐AFLP proved an adequate technique to investigate DNA methylation changes in post‐hatch zebra finches, the technique is limited in its ability to provide information about the sequence and function of methylated loci (Fulneček and Kovařík ). Consequently, correlations between the methylation patterns observed in our study, and their phenotypic effects are yet to be elucidated (Shaham et al ). It would be useful for future work to focus on next‐generation sequence‐based techniques, such as bisulfite sequencing (Bentz et al , Lea et al , Weyrich et al ).…”
Section: Discussionmentioning
confidence: 84%
“…A major finding was that silencing of the Dnmt3 gene (involved in methylation establishment) in larvae produced queens rather than workers (Kucharski et al 2008). DNA methylation has also been linked with alternative splicing differences between castes in two ant species (Bonasio et al 2012) and is thought to be involved in caste determination in Copidosoma koehleri, a species of primitively social wasp (Shaham et al 2016). However, it is clear DNA methylation is not a conserved mechanism in Hymenoptera for caste differentiation.…”
Section: Impact Summarymentioning
confidence: 99%
“…) and is thought to be involved in caste determination in Copidosoma koehleri , a species of primitively social wasp (Shaham et al. ). However, it is clear DNA methylation is not a conserved mechanism in Hymenoptera for caste differentiation.…”
mentioning
confidence: 99%
“…Here we want to emphasize the importance of validating the demethylating effect of 5-aza-dC when testing hypotheses about the relationship between DNA methylation and phenotypic expression. In addition to sex allocation (Cook et al 2015) and induction of diapause (Pegoraro et al 2016), several other phenotypes have been implied in parasitoid wasps to be regulated epigenetically, including caste determination (Shaham et al 2016) and fatty acid composition (Sak 2017). For a more reliable interpretation of all experiments with orally administered 5-aza-dC to parasitoids, it will be necessary to have a better idea of the extent and pervasiveness of demethylating effect of this method.…”
Section: Introductionmentioning
confidence: 99%