“…LOH events are a source of genomic rearrangements and can contribute to the rapid onset of phenotypic diversity (Dutta, Dutreux, & Schacherer, 2021;Sampaio et al, 2020;Smukowski Heil et al, 2017). LOH has gained attention for its frequent association with fitness, adaptation, polyploid stabilization, or even pathogenesis in yeasts but also in other organisms such as the oomycete Phytophthora capsica, hybrids of the cultivated rice Oryza or the Cobitis fish species (Beekman & Ene, 2020;Forche et al, 2011;Janko et al, 2021;Lamour et al, 2012;Morales & Dujon, 2012;Todd, Wikoff, Forche, & Selmecki, 2019 Wang, Li, & Chatterton, 1999). Compared to S. cerevisiae where LOH represents 50% of the genome, B. bruxellensis presents a low level of LOH, which is variable across subpopulations (Gounot et al, 2020;Peter et al, 2018).…”