Genome editing for crop improvement: A perspective from India

Bhattacharya, Anjanabha; Parkhi, Vilas; Char, Bharat

doi:10.1007/s11627-021-10184-2

Cited by 20 publications

(5 citation statements)

References 70 publications

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“…221 Six agencies under authority of the Ministry of Environment, Forest and Climate Change, in close collaboration with State Governments and the Department of Biotechnology, oversee the development of genetically modified crops. 222 The six agencies are: (1) RDAC: rDNA Advisory Committee; (2) IBSC: Institutional Biosafety Committee; (3) RCGM: Review Committee on Genetic Manipulation; (4) GEAC: Genetic Engineering Appraisal Committee; (5) SBCC: State Biotechnology Coordination Committee; and (6) DLC: District Level Committee.…”

Section: Gm Regulation In Major Economies (Based On Gdp Ranking)mentioning

confidence: 99%

Processes for regulating genetically modified and gene edited plants

Caradus

2023

GM Crops & Food

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Innovation in agriculture has been essential in improving productivity of crops and forages to support a growing population, improving living standards while contributing toward maintaining environment integrity, human health, and wellbeing through provision of more nutritious, varied, and abundant food sources. A crucial part of that innovation has involved a range of techniques for both expanding and exploiting the genetic potential of plants. However, some techniques used for generating new variation for plant breeders to exploit are deemed higher risk than others despite end products of both processes at times being for all intents and purposes identical for the benefits they provide. As a result, public concerns often triggered by poor communication from innovators, resulting in mistrust and suspicion has, in turn, caused the development of a range of regulatory systems. The logic and motivations for modes of regulation used are reviewed and how the benefits from use of these technologies can be delivered more efficiently and effectively is discussed.

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Section: Gm Regulation In Major Economies (Based On Gdp Ranking)mentioning

confidence: 99%

Processes for regulating genetically modified and gene edited plants

Caradus

2023

GM Crops & Food

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“…Since developing homozygous lines could take at least 10 years through conventional breeding, it alone will not be sufficient to bridge the gap between current level of crop production. Hence the rate of genetic gain has remained considerably low with time ( Bhattacharya et al, 2021 ). Several strategies to create and unlock favourable genetic variations through molecular and genomic approaches including mutation, gene mapping and discovery, transgenics, and genome editing to enhance genetic gains in crops have been reviewed ( Xu et al, 2017 ).…”

Section: Accelerating Genetic Gains Through Genome Editingmentioning

confidence: 99%

CRISPR for accelerating genetic gains in under-utilized crops of the drylands: Progress and prospects

Sharma

Palakolanu²,

Bhattacharya³

et al. 2022

Front. Genet.

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Technologies and innovations are critical for addressing the future food system needs where genetic resources are an essential component of the change process. Advanced breeding tools like “genome editing” are vital for modernizing crop breeding to provide game-changing solutions to some of the “must needed” traits in agriculture. CRISPR/Cas-based tools have been rapidly repurposed for editing applications based on their improved efficiency, specificity and reduced off-target effects. Additionally, precise gene-editing tools such as base editing, prime editing, and multiplexing provide precision in stacking of multiple traits in an elite variety, and facilitating specific and targeted crop improvement. This has helped in advancing research and delivery of products in a short time span, thereby enhancing the rate of genetic gains. A special focus has been on food security in the drylands through crops including millets, teff, fonio, quinoa, Bambara groundnut, pigeonpea and cassava. While these crops contribute significantly to the agricultural economy and resilience of the dryland, improvement of several traits including increased stress tolerance, nutritional value, and yields are urgently required. Although CRISPR has potential to deliver disruptive innovations, prioritization of traits should consider breeding product profiles and market segments for designing and accelerating delivery of locally adapted and preferred crop varieties for the drylands. In this context, the scope of regulatory environment has been stated, implying the dire impacts of unreasonable scrutiny of genome-edited plants on the evolution and progress of much-needed technological advances.

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“…Significantly, knock-out-of-six AITR genes showed improved drought and salinity stress tolerance in Arabidopsis exclusive of fitness cost [75]. Similarly, knock-out of three AITR genes aitr2, aitr5, and aitr6 (aitr256) in Arabidopsis plant with triple mutant showed tolerance to drought and salt stress through CRISPR/Cas9 technology which yielded quintuple mutants to increase the tolerant capacity for stress in the plants [76]. In rice, CRISPR/Cas9 mediated knockout of a zinc finger transcription factor and a miRNA, OsmiR535, conferred increased tolerance against abiotic stresses in rice plants.…”

Section: Impact Of Crispr-cas9-based Gene Editing On Plant Productivi...mentioning

confidence: 99%

Application of CRISPR-Cas9-Mediated Gene Editing for Abiotic Stress Management in Crop Plants

Kumar¹,

Prusty²,

Pandey³

et al. 2022

Preprint

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Abiotic stresses, including drought, salinity, cold, heat, and heavy metals, extensively reduce global agricultural production. Approaches such as conventional breeding and transgenic breeding have been widely used to cope with these environmental stresses. The clustered regularly interspaced short palindromic repeat- Cas (CRISPR/Cas) based gene-editing tool has revolutionized due to its simplicity, accessibility, adaptability, flexibility, and wide applicability. This system has a great potential to build up crop varieties with enhanced tolerance against abiotic stresses. In this review, we summarize the most recent findings on understanding the mechanism of abiotic stress response in plants and the application of CRISPR/Cas mediated gene-editing system towards enhanced tolerance to drought, salinity, cold, heat, and heavy metals stresses. Furthermore, in this review, we highlighted the recent advancements in prime editing and base editing tools for crop improvement.

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Genome editing for crop improvement: A perspective from India

Cited by 20 publications

References 70 publications

Processes for regulating genetically modified and gene edited plants

Processes for regulating genetically modified and gene edited plants

CRISPR for accelerating genetic gains in under-utilized crops of the drylands: Progress and prospects

Application of CRISPR-Cas9-Mediated Gene Editing for Abiotic Stress Management in Crop Plants

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