Genome characterization of the novel lytic phage vB_AbaAut_ChT04 and the antimicrobial activity of its lysin peptide against Acinetobacter baumannii isolates from different time periods

Leungtongkam, Udomluk; Kitti, Thawatchai; Khongfak, Supat; Thummeepak, Rapee; Tasanapak, Kannipa; Wongwigkarn, Jintana; Khanthawong, Sophit; Belkhiri, Aouatif; Ribeiro, Henrique G.; Turner, John S.; Malik, Danish J.; Sitthisak, Sutthirat

doi:10.1007/s00705-023-05862-y

Arch Virol

2023

DOI: 10.1007/s00705-023-05862-y

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Genome characterization of the novel lytic phage vB_AbaAut_ChT04 and the antimicrobial activity of its lysin peptide against Acinetobacter baumannii isolates from different time periods

Udomluk Leungtongkam,

Thawatchai Kitti,

Supat Khongfak

et al.

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2024

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Engineering strategies and challenges of endolysin as an antibacterial agent against Gram‐negative bacteria

Zheng,

Zhang

2024

Microbial Biotechnology

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Bacteriophage endolysin is a novel antibacterial agent that has attracted much attention in the prevention and control of drug‐resistant bacteria due to its unique mechanism of hydrolysing peptidoglycans. Although endolysin exhibits excellent bactericidal effects on Gram‐positive bacteria, the presence of the outer membrane of Gram‐negative bacteria makes it difficult to lyse them extracellularly, thus limiting their application field. To enhance the extracellular activity of endolysin and facilitate its crossing through the outer membrane of Gram‐negative bacteria, researchers have adopted physical, chemical, and molecular methods. This review summarizes the characterization of endolysin targeting Gram‐negative bacteria, strategies for endolysin modification, and the challenges and future of engineering endolysin against Gram‐negative bacteria in clinical applications, to promote the application of endolysin in the prevention and control of Gram‐negative bacteria.

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Engineering strategies and challenges of endolysin as an antibacterial agent against Gram‐negative bacteria

Zheng,

Zhang

2024

Microbial Biotechnology

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Genome characterization of the novel lytic phage vB_AbaAut_ChT04 and the antimicrobial activity of its lysin peptide against Acinetobacter baumannii isolates from different time periods

Cited by 1 publication

References 44 publications

Engineering strategies and challenges of endolysin as an antibacterial agent against Gram‐negative bacteria

Engineering strategies and challenges of endolysin as an antibacterial agent against Gram‐negative bacteria

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