Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray

Jiang, Di; Xu, Xinming; Ainiwaer, Lazate; Zhang, Yanhua; Tian, Kechuan; Yu, Li‐Juan; Wu, Weiwei; Tulafu, Hanikezi; Fu, Xuefeng; Yasen, Marzeya

doi:10.1016/s2095-3119(13)60606-1

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…In anagen, COL1A1 , C1QTNF6 , COL1A2 and AQP3 were identified as hub genes. COL1A1 and COL1A2 encode the proalpha1 and two chains of type I collagen which is the major protein of the extracellular matrix (ECM) [ 55 , 56 , 57 ]. ECM widely exists in dermal sheath and dermal papilla (DP) in anagen [ 58 , 59 , 60 ], diminishes during catagen, and is minimal in the telogen follicle [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Wang

Sui

Mao

et al. 2021

Genes

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The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for cashmere goat with double-coat, the periodic change may be due to other regulatory molecules and signal pathways. To understand the mechanism of periodic development of hair follicle, we performed a weighted gene coexpression network analysis (WGCNA) to mine key genes and establish an interaction network by utilizing the NCBI public dataset. Ten coexpression modules, including 7689 protein-coding genes, were constructed by WGCNA, six of which are considered to be significantly related to the development of the hair follicle cycle. A functional enrichment analysis for each model showed that they are closely related to ECM- receptor interaction, focal adhesion, PI3K-Akt signaling pathway, estrogen signaling pathway, and so on. Combined with the analysis of differential expressed genes, 12 hub genes from coexpression modules were selected as candidate markers, i.e., COL1A1, C1QTNF6, COL1A2, AQP3, KRTAP3-1, KRTAP11-1, FA2H, NDUFS5, DERL2, MRPL14, ANTKMT and XAB2, which might be applied to improve cashmere production.

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Section: Discussionmentioning

confidence: 99%

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Wang

Sui

Mao

et al. 2021

Genes

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“…5e), suggesting that these SVs are crucial in fiber formation and development in cashmere goats 30,31 . We further examined the 57 SVs that uniquely occurred in T2T-goat1.0 but were not in the assemblies of the other five goats, and found that FGFBP1 32,33 , KAP9-2 34 and COL1A1 35 are known to be associated with hair and cashmere development (Supplementary Table 8). A total of 5224~6584 SVs were uniquely identified in the five female goats (Supplementary Fig.…”

Section: Structural Variants Based On Long Readsmentioning

confidence: 99%

Telomere-to-telomere genome assembly of a male goat reveals novel variants associated with cashmere traits

Wu,

Luo,

Zhang

et al. 2024

Preprint

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A complete goat (Capra hircus) reference genome enhances analyses of genetic variation, thus providing novel insights into domestication and selection in goats and related species. Here, we assembled a telomere-to-telomere (T2T) gap-free genome (2.86 Gb) from a cashmere goat (T2T-goat1.0), which included a Y chromosome of 20.9 Mb. With a base accuracy of >99.999%, T2T-goat1.0 corrected numerous genome-wide structural and base errors in previous assemblies and added 288.5 Mb of previously unresolved regions (PURs) and 446 newly assembled genes to the reference genome. We sequenced the genomes of five representative goat breeds for PacBio reads, and used T2T-goat1.0 as a reference to identify a total of 63,417 structural variations (SVs) with up to 4711 SVs (7.41%) in the PURs and 507 overlapping genes significantly enriched (Padj. < 0.05) in the keratin filament pathway. T2T-goat1.0 was applied in population analyses of global wild and domestic goats, which revealed 32,419 SVs and 25,397,794 SNPs, including 870 SVs and 545,026 SNPs in the PURs. Also, our analyses revealed a set of novel selective variants and genes associated with domestication (e.g., NKG2D and ABCC4) and cashmere traits (e.g., ABCC4 and ASIP).

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Association analysis for SNPs of BAAT and COL1A1 genes with cashmere production performance and other production traits in Liaoning cashmere goats

Cai

Bai

et al. 2022

Animal Biotechnology

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Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray

Cited by 5 publications

References 33 publications

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Telomere-to-telomere genome assembly of a male goat reveals novel variants associated with cashmere traits

Association analysis for SNPs of BAAT and COL1A1 genes with cashmere production performance and other production traits in Liaoning cashmere goats

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