Genome analysis of Lachnoclostridium phocaeense isolated from a patient after kidney transplantation in Marseille

Dandachi, Iman; Anani, Hussein; Hadjadj, Linda; Brahimi, S.; Lagier, Jean-Christophe; Daoud, Ziad; Rolain, Jean‐Marc

doi:10.1016/j.nmni.2021.100863

Cited by 16 publications

(7 citation statements)

References 19 publications

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“…Comparable results were also reported by Zhu and co-workers [ 60 ] where the beta-diversity index of cecal microbiota was significantly higher than that of PC group at the same sampling timepoints. Accordingly, Gao et al [ 61 ] reported opposing effects of probiotic and antibiotic administrations on the age-dependent maturation of intestinal microbiota. The probiotic treatment showed an early-maturing trend, reaching a plateau at day 15 and indicating an accelerated maturation of the gut microbiota, whereas antibiotics showed a delayed microbiota development, and the beta-diversity of intestinal microbiota changed more heavily in the antibiotic group from day 1 to 42.…”

Section: Discussionmentioning

confidence: 99%

“…Genus Lachnoclostridium was significantly increased by PRO-WS compared to the antibiotic positive control. This genus includes bacteria from several clostridial clusters which are known to have anti-inflammatory effects and play important role in homeostasis [ 61 ]. Gao et al [ 62 ] found eight genera that were significantly changed on day 28; however, no genera were found significantly changed on day 42.…”

Section: Discussionmentioning

confidence: 99%

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The Efficiency of Probiotics Administrated via Different Routes and Doses in Enhancing Production Performance, Meat Quality, Gut Morphology, and Microbial Profile of Broiler Chickens

Soumeh

Cedeno

Niknafs

et al. 2021

Animals

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To study the efficiency of Bacillus spp. probiotics administered via different routes and doses, a 6-week grow-out trial was conducted using a total of 378 day-old mixed-sex ROSS308 broiler chickens in a completely randomized block design. Six experimental diets included probiotics added at two different inclusion rates into the feed (250 g/ton; PRO250, or 500 g/ton; PRO500), or in the drinking water (25 g/L; PRO-WS), or as a feed synbiotic (250 g probiotic + 250 g/ton prebiotic; SYN), compared to a negative (NC; without additives) and positive control (PC; with antibiotics) diets. The PRO-WS enhanced feed intake (p < 0.05) and tended to improve average daily gain and final body weight (p = 0.14). Broiler gut morphology in the duodenum including the villus height (p = 0.04), villus width (p = 0.05) and crypt depth (p = 0.02) were improved by PRO500. Firmicutes was the most abundant phylum, followed by Bacteroidetes. Streptococcaceae, Lachnoospiraceae, Peptostreptococcaceae, Ruminococcaceae, and Erysipe-lotrichaceae were the top five most abundant families. Antibiotic inclusion in PC reduced microbial beta-diversity and increased similarity compared to probiotic inclusion (p = 0.05). Probiotic inclusion reduced the relative abundance of Bacteroides fragilis, which is a commonly isolated pathogen and is considered as a marker for antimicrobial resistance. Overall, probiotic supplementation via feed or water may potentially improve the production performance of the broiler chickens, and water-soluble probiotics are potentially more effective. Probiotics, especially when added to water, suggest a promising feed additive to support gut microbial maturation and diversity, and may reduce resistant bacteria in broiler chickens. However, it is suggested that the best route for the administration of probiotics be further examined under commercial conditions to find the most effective and practical application method that yields the most consistent results.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Efficiency of Probiotics Administrated via Different Routes and Doses in Enhancing Production Performance, Meat Quality, Gut Morphology, and Microbial Profile of Broiler Chickens

Soumeh

Cedeno

Niknafs

et al. 2021

Animals

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“…Lachnoclostridium is a genus of gram-positive, obligate anaerobic, spore-forming, motile bacteria. Organisms in this genus can grow in moderate ‘mesophilic’ as well as in extremely high ‘thermophilic’ temperatures 37 , which could confer it a fitness advantage in HTH. Lachnoclostridium is described with higher microbial capacity for bile acid conversion through a 7α-dehydratase process 38 , explained the robust increase in LCA abundance.…”

Section: Discussionmentioning

confidence: 99%

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Chen,

Hu,

Tang

et al. 2024

Commun Biol

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High temperature and humidity in the environment are known to be associated with discomfort and disease, yet the underlying mechanisms remain unclear. We observed a decrease in plasma glucagon-like peptide-1 levels in response to high-temperature and humidity conditions. Through 16S rRNA gene sequencing, alterations in the gut microbiota composition were identified following exposure to high temperature and humidity conditions. Notably, changes in the gut microbiota have been implicated in bile acid synthesis. Further analysis revealed a decrease in lithocholic acid levels in high-temperature and humidity conditions. Subsequent in vitro experiments demonstrated that lithocholic acid increases glucagon-like peptide-1 secretion in NCI-H716 cells. Proteomic analysis indicated upregulation of farnesoid X receptor expression in the ileum. In vitro experiments revealed that the combination of lithocholic acid with farnesoid X receptor inhibitors resulted in a significant increase in GLP-1 levels compared to lithocholic acid alone. In this study, we elucidate the mechanism by which reduced lithocholic acid suppresses glucagon-like peptide 1 via farnesoid X receptor activation under high-temperature and humidity condition.

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“…Thus, it can be prospected for its role in ethanol metabolism in drinkers and metabolism of hydrocarbons in the oral cavity of smoker BQC. Lachnoclostridium is a common human gut bacterium displaying homeostatic and anti-inflammatory behaviour [ 74 , 82 ]. Cycloclasticus is generally found in the marine habitat which degrades polycyclic aromatic hydrocarbon (PAH) compounds aerobically [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

Identifying oral microbiome alterations in adult betel quid chewing population of Delhi, India

et al. 2023

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The study targets to establish a factorial association of oral microbiome alterations (oral dysbiosis) with betel quid chewing habits through a comparison of the oral microbiome of Betel quid chewers and non-chewing individuals. Oral microbiome analysis of 22 adult individuals in the Delhi region of India through the 16S sequencing approach was carried out to observe the differences in taxonomic abundance and diversity. A significant difference in diversity and richness among Betel Quid Chewers (BQC) and Betel Quid Non-Chewers (BQNC) groups was observed. There were significant differences in alpha diversity among the BQC in comparison to BQNC. However, in the age group of 21–30 years old young BQC and BQNC there was no significant difference in alpha diversity. Similar result was obtained while comparing BQC and Smoker-alcoholic BQC. BQ smoker-chewers expressed significant variance in comparison to BQC, based on cluster pattern analysis. The OTU-based Venn Diagram Analysis revealed an altered microbiota, for BQ chewing group with 0–10 years exposure in comparison to those with 10 years and above. The change in the microbial niche in early chewers may be due to abrupt chemical component exposure affecting the oral cavity, and thereafter establishing a unique microenvironment in the long-term BQC. Linear discriminant analysis revealed, 55 significant features among BQC and Alcoholic-Smoker BQC; and 20 significant features among BQC and Smoker BQC respectively. The study shows the abundance of novel bacterial genera in the BQC oral cavity in addition to the commonly found ones. Since the oral microbiome plays a significant role in maintaining local homeostasis, investigating the link between its imbalance in such conditions that are known to have an association with oral diseases including cancers may lead to the identification of specific microbiome-based signatures for its early diagnosis.

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Genome analysis of Lachnoclostridium phocaeense isolated from a patient after kidney transplantation in Marseille

Cited by 16 publications

References 19 publications

The Efficiency of Probiotics Administrated via Different Routes and Doses in Enhancing Production Performance, Meat Quality, Gut Morphology, and Microbial Profile of Broiler Chickens

The Efficiency of Probiotics Administrated via Different Routes and Doses in Enhancing Production Performance, Meat Quality, Gut Morphology, and Microbial Profile of Broiler Chickens

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Identifying oral microbiome alterations in adult betel quid chewing population of Delhi, India

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