Abstract:Natural remedies are used as stand-alone treatments or as additives to modern medicine to control hyperglycemia. Here, we investigate the antidiabetic potential of the Palauan traditional leaf decoction of Phaleria nisidai (PNe) using a reverse pharmacology approach. In diet induced obese mice, dietary supplementation with PNe improves insulin sensitivity and promotes glucose uptake into adipose depots. In vitro, PNe triggers insulin-independent glucose disposal into murine and human adipocytes by upregulating… Show more
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