Genitourinary Dysfunction Prevalence in Parkinson Disease Patients

Abstract

The goal of this study was to estimate the prevalence of patient-reported genitourinary dysfunction symptoms in Parkinson’s disease patients from the Southeastern Romania. The study was performed on 86 patients with idiopathic Parkinson’s disease from 5 Outpatients Clinics of Constanta, 56% males, mean age 70.6 years, mean disease duration 6.33 years. The patients have been assessed for the presence of genitourinary symptoms using the Scale for Outcomes in Parkinson’s Disease for Autonomic Symptoms (SCOPA-AUT) as a self-administered questionnaire. The vast majority of study population (98.8%) reported at least one genitourinary dysfunction. The most common urinary symptom was nocturia (95.3%, 95% CI 90.8-99.7), followed by pollakiuria (82.5%, 95% CI 74.4-90.5), difficulty passing urine and urge to urinate (each present in 76.7% of studied PD patients, 95% CI 67.4-85.3), incomplete bladder emptying (75.5%, 95% CI 66.4-84.5), urinary incontinence (67.4%, 95% CI 57.5-77.3). As frequency, most of the study subjects experienced genitourinary symptoms only “sometimes”. None of the investigated PD patients affected by genitourinary symptoms used specific medication therapy.

Prevalence of lower urinary tract symptoms, urinary incontinence and retention in Parkinson's disease: A systematic review and meta-analysis

“…One study revealed that the patients without residual urine were younger than patients with residual urine (67.5 vs. 70.1 years) (Zhang and Zhang, 2015 ). A higher weighted prevalence was calculated in older people than younger people (76 vs. 18%) (Campos-Sousa et al, 2003 ; Irene, 2019 ), suggesting PD patients with older age might be more likely to experience urinary retention. Overall, when distinguishing PD from MSA with urinary retention symptoms, we should be more cautious and consider relevant factors such as age, disease duration, and disease severity.…”

“…PD patients were generally considered less likely to develop those two symptoms, and the presence of unexplained voiding difficulties with elevated post-void residual (PVR) volume ≥ 100 ml or unexplained urinary urge incontinence was often considered to support the diagnosis of multiple system atrophy (MSA) (Yamamoto et al, 2016 ; Wenning et al, 2022 ). However, urinary incontinence and retention are not rare, even PVR volume ≥ 100 ml can also occur in PD (Irene, 2019 ; Tateno et al, 2021 ). For example, one study with large sample size found that the prevalence of urinary incontinence was 43% in PD (Wüllner et al, 2007 ).…”

“…Utilizing the Danish Prostate Symptom Score (Dan-PSS), the prevalence of urge incontinence in PD was up to 65.8% (Akkoç et al, 2017). Another study found the prevalence of incomplete bladder emptying was 75.5% in PD (Irene, 2019). Until now, no meta-analysis has been carried out to estimate the overall prevalence of LUTS, urinary incontinence, and retention in PD.…”