Genital ulcers caused by sexually transmitted agents

Ramos, Maria Eliza Barbosa; Nicola, Maria Rita Castilhos; Bezerra, Natália Tenório Cavalcante; Sardinha, José Carlos; Morais, Julia Sampaio de Souza; Schettini, Antônio Pedro Mendes

doi:10.1016/j.abd.2022.01.004

Cited by 12 publications

(6 citation statements)

References 41 publications

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“…Syphilis and other STI must be considered in the differential diagnosis, especially herpes simplex, chancroid and donovanosis. Rapid immunochromatographic tests are a valuable tool for the evaluation of genital ulcers (8) . Other infectious diseases may also cause genital ulcer diseases, and long-lasting lesions demand diagnostic exclusion of neoplastic processes, especially when occurring in the elderly (8) .…”

Section: Discussionmentioning

confidence: 99%

Giant chancre in an octogenary patient. Always remember syphilis!

Ramos,

Ruwel

2024

J Bras Doenças Sex Transm

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Introduction: Syphilis is a sexually transmitted infection (STI) caused by the Treponema pallidum and has become epidemic in the past two decades. The disease is often asymptomatic, and its manifestations are diverse. It may affect multiple systems, posing the risk of serious consequences or even death. Objective: To present a case of an exuberant syphilis-related lesion in an elderly man. Case report: An 85-year-old man presented with a painless penile lesion. He reported having had oral sexual contact (felatio) with a female sex worker six weeks prior the presentation of the lesion. During the physical exam, an ulcer measuring three to four cm was observed, reaching subcutaneous tissue down to the Buck’s fascia, and presenting a clean beefy red base, and an infiltrated edge. Bilateral and movable enlarged and painless lymph nodes were found. The rapid immunochromatographic test was positive for syphilis and negative for HIV, hepatitis B, and hepatitis C. Treatment consisted of an in loco injection of 2,400,000 IU of benzathine penicillin. Conclusion:In spite of being more common among younger individuals, syphilis should be always considered in the differential diagnosis of genital ulcers, regardless of the patient’s age. Many aged people keep an active sexual life especially with the increase of longevity and effective therapeutic measures for erectile disfunction. The false belief that sexual activity ceases to exist in older age groups must, therefore, be abandoned.

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Section: Discussionmentioning

confidence: 99%

Giant chancre in an octogenary patient. Always remember syphilis!

Ramos,

Ruwel

2024

J Bras Doenças Sex Transm

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“…The present consensus among syphilologists is that the clinical manifestations of syphilitic infection emerge from treponeme-driven inflammatory processes ( 16 ). Furthermore, the pathology of syphilis is characterized by vascular manifestations such as periarteritis and endarteritis.…”

Section: Discussionmentioning

confidence: 99%

Tp47-Induced Monocyte-Derived Microvesicles Promote the Adherence of THP-1 Cells to Human Umbilical Vein Endothelial Cells via an ERK1/2–NF-κB Signaling Cascade

et al. 2023

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“…Accordingly, oral acyclovir 200 mg five times a day for 10 days was prescribed. 4 Six months after treatment, the lesions resolved, presenting only as a residual area of hypochromia (Figure 2C). Nevertheless, recurrence was common between 2012 and 2017 (Figure 2 A-B).…”

Section: Case Reportmentioning

confidence: 99%

“…Histopathology was reviewed, and immunohistochemistry was performed, the latter of which was positive for HSV. Accordingly, oral acyclovir 200 mg five times a day for 10 days was prescribed 4 …”

Section: Case Reportmentioning

confidence: 99%