Genital ulcers associated with systemic lupus erythematosus – what are the possible causes? A Case Report

Kudsi, Maysoun; Drie, Tasneem; Haidar, Ghina; Al-Sayed, Safaa; Roumieh, Enas

doi:10.12890/2023_003972

Cited by 1 publication

(2 citation statements)

References 16 publications

(39 reference statements)

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“…Late-onset SLE accounts for 2–12% of SLE patients with a minimum age of onset of 50 years and older, leading to significant delays in diagnosis 3 . The period from symptom onset to diagnosis has been reported to be up to 60 months for late-onset SLE, compared to 19–24 months for adult-onset SLE 2 , 3 . Late-onset SLE differs from early-onset SLE in terms of gender and ethnicity prevalence, clinical symptoms and signs, development of organ damage, disease activity and severity, and prognosis 3 .…”

Section: Discussionmentioning

confidence: 99%

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Pancytopenia as a first presentation of late-onset systemic lupus erythematosus: a case report

Haidar,

Khalayli,

Drie

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction: Systemic Lupus Erythematosus is a systemic immune disease that classically occurs in young to middle-aged women and may present with cutaneous, renal, hematologic, neurological, and/or other symptoms at the time of diagnosis. Late-onset Systemic Lupus Erythematosus or Systemic Lupus Erythematosus in the elderly is a subtype that differs from classic Systemic Lupus Erythematosus in terms of age group, clinical symptoms, organ involvement and severity. Case presentation: A 63 years old female noted to have pancytopenia. The patient was diagnosed with lupus upon obtaining clinical presentations and serological marker, along with high titers of the antinuclear antibody and/or anti-double-stranded DNA antibody. The patient was managed with glucocorticoids and mycophenolate mofetil therapy, which led to a rapid response. Discussion: Late-onset SLE accounts for 2–12% of SLE patients with a minimum age of onset of 50 years and older, leading to significant delays in diagnosis. Late-onset SLE differs from early-onset SLE in terms of gender and ethnicity prevalence, clinical symptoms and signs, development of organ damage, disease activity and severity, and prognosis .Some studies have also shown that late-stage SLE patients have higher rates of RF and anti-Ro/anti-La antibody positivity, lower complement titer, and higher incidence of elevated creatinine and decreased creatinine clearance .First-line treatment of pancytopenia is glucocorticoid. In refractory cases, rituximab and immunosuppressants can be used. Conclusion: It is important to assess any unusual presentation of Systemic Lupus Erythematosus when clinical suspicion remains high and conducting further laboratory and imaging investigation.

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Section: Discussionmentioning

confidence: 99%

“…Frequent symptoms include fever, joint pain, weight loss, and fatigue. In addition, other systemic organs symptoms may find at the disease onset or develop as the disease progresses 2 . Late-onset SLE was found to occur in patients over 50–60 years of age 1 .…”

Section: Introductionmentioning

confidence: 99%