Genital Tuberculosis Can Present as Disseminated Ovarian Carcinoma with Ascites and Raised Ca-125: A Case Report

Manidakis, Louis George; Angelakis, E.; Sifakis, Stavros; Stefanaki, P.; Kalogeraki, A; Manidaki, A.; Koumantakis, E.

doi:10.1159/000058065

Cited by 23 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pre operative paracentesis were unhelpful because the bacteriology, culture, cytology(14,100%) and PCR(10,71%) study of ascitic fluid yield negative result similar to earlier reports (Rozati et al) 17 .…”

Section: Discussionsupporting

confidence: 80%

Abdomino Pelvic Tuberculosis Versus Advanced Ovarian Malignancy : A Diagnostic Dilemma

Noor

Nahar

Bilkis

et al. 2015

Chatt Maa Shi Hosp Med Coll J

View full text Add to dashboard Cite

Pelvic tuberculosis a common infectious cause of human death remains a global health problem, primarily in developing countries .Diagnosis of extra-pulmonary tuberculosis is challenging as it is rarely pinpointed by clinical symptoms, laboratory and radiological findings of low specificity. Pelvic tuberculosis should be considered in young women presented with pelvic mass, ascites and elevated serum CA 125. A series of fourteen cases between the 20 to 70 years are being reported having spectrum of clinical feature and creating diagnostic dilemma. The final diagnosis was made by histopathology after FNAC, laparoscopy or laparotomy are reviewed here. So the aim was formulation of high degree of suspicion aided by intensive investigation for timely diagnosis of genital tuberculosis, to see the response of antituberculer therapy and avoid unnecessary extended surgery.

show abstract

Section: Discussionsupporting

confidence: 80%

Abdomino Pelvic Tuberculosis Versus Advanced Ovarian Malignancy : A Diagnostic Dilemma

Noor

Nahar

Bilkis

et al. 2015

Chatt Maa Shi Hosp Med Coll J

View full text Add to dashboard Cite

show abstract

“…In many patients abdominal and vaginal examinations might be normal. The nonspecific clinical features and negative preoperative findings of FGTB in a female patient frequently contribute to misdiagnosis [15]. …”

Section: Discussionmentioning

confidence: 99%

Pelvic Inflammatory Disease: A Retrospective Clinical Analysis of 1,922 Cases in North China

Zhao¹,

Hao²

2014

Gynecol Obstet Invest

View full text Add to dashboard Cite

Purpose: To identify the cause of pelvic inflammatory disease (PID) in Shanxi, North China. Methods: Retrospective analysis of 1,922 women with PID who underwent laparoscopy for infertility. Results: 1,922 cases (42.3%) of PID were detected in 4,540 cases of infertility, wherein the incidence rates of nonspecific PID and female genital tuberculosis (FGTB) were 57.9 and 42.1%, respectively. From 1985 to 1995, FGTB (25.1%) was the first reason for infertility, while from 1996 to 2006, nonspecific PID (33.9%) emerged as the most common cause of infertility. Further, FGTB (74.7%) was the major factor causing occluded fallopian tubes, followed by nonspecific PID (61.1%), and the damage of the former was more serious than the latter. Conclusions: PID is the main cause of tubal infertility, but the etiology of PID has changed from FGTB to nonspecific PID in the last 10 years in Shanxi.

show abstract

“…In women, the routine imaging investigations by ultrasonographic or CT scan of the abdomen could occasionally reveal a cystic mass in the ovary or ascitis with features suggestive of secondary spreading over the omentum and peritoneal surface 12 . For this reason, the initial clinical interpretation on the adnexal masses, cul‐de‐sac nodularity, ascites, omental and peritoneal thickening, weight loss and elevated CA‐125 serum levels led to an erroneous preliminary diagnosis of disseminated ovarian cancer 13,14 . The suspect of ovarian cancer should be confirmed by clinical investigations with CA125 serum levels in the normal range (0–35 U/mL) and only when there is no any analytical evidence of TB 15 …”

Section: Introductionmentioning

confidence: 99%

Abdominopelvic tuberculosis in gynaecology: Laparoscopical and new laboratory findings

Tinelli¹,

Malvasi²,

Vergara³

et al. 2008

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

Introduction: Tuberculosis (TB) is a rare curable infective disease, caused mainly by Mycobacterium tuberculosis, which in abdominopelvic (AP) localisation, can mimic a disseminated carcinomatosis. Symptoms of AP-TB are non-specific, so diagnosis is difficult and elusive as the affected patients have normal chest X-ray and elevated levels of CA125. Female ultrasonographic features of AP-TB mimic peritoneal carcinomatosis, and the computed tomography has also been suggested to be helpful, but the final diagnosis was reached by histology and serology. Aim of the study: To propose the validity of the combination of laparoscopy (LPS), histopathology and enzyme-linked immuno-spot (ELIspot) in the diagnosis of AP-TB. Methods: In the last two years, we had six women with suspect of AP-TB, who, after the routine exams, were referred for a diagnostic LPS that revealed turbid-free fluid in pelvis or ascites (collected for serology), multiple peritoneal and/or bowel tubercles (randomly sampled), fibrous bands, adhesions, hyperaemic and oedematous bowel loops. Results: LPS diagnosis was confirmed by intra-LPS biopsy of nodules and histological examination of specimens: epithelioid granulomas with central caseous necrosis in five patients (83.3%) and a non-caseating granulomatous inflammation in the last one. An outer layer of epithelioid histiocytes and Langhans cells was present in all patients. Using the ELIspot technique performed on free fluids, the final diagnosis of TB was made in all patients. Conclusions: Even if gynaecological LPS appearance of the peritoneum can mimic other conditions, ELIspot and histopathological exam can confirm the suspect of AP-TB.

show abstract

Genital Tuberculosis Can Present as Disseminated Ovarian Carcinoma with Ascites and Raised Ca-125: A Case Report

Cited by 23 publications

References 7 publications

Abdomino Pelvic Tuberculosis Versus Advanced Ovarian Malignancy : A Diagnostic Dilemma

Abdomino Pelvic Tuberculosis Versus Advanced Ovarian Malignancy : A Diagnostic Dilemma

Pelvic Inflammatory Disease: A Retrospective Clinical Analysis of 1,922 Cases in North China

Abdominopelvic tuberculosis in gynaecology: Laparoscopical and new laboratory findings

Contact Info

Product

Resources

About