Genital <i>Mycoplasma</i> infection among Mexican women with systemic lupus erythematosus

Méndez‐Martínez, Socorro; Garcı́a-Carrasco, Mario; Cedillo-Ramírez, María L.; Mendoza‐Pinto, Claudia; Etchegaray‐Morales, Ivet; Constantino, Gil-Juárez; Montiel-Jarquín, Álvaro José; Taboada-Cole, Alejandro; Jiménez-Herrera, Erick Alejandro; Muñoz-Guarneros, Margarita; Cervera, Ricard

doi:10.1002/ijgo.12154

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…Infections are a trigger for SLE, and disease activity is linked to Mycoplasma spp. [ 44 ], human papillomavirus [ 45 ] and H. pylori [ 46 ]. The main microorganisms associated with SLE development are Epstein-Barr virus, parvovirus B 19, human T-lymphotropic virus-1, and endogenous retroviruses [ 47 ].…”

Section: Helicobacter Pylori and Systemic Lupus Erythematosusmentioning

confidence: 99%

Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome

Etchegaray‐Morales

Jiménez-Herrera²,

Mendoza‐Pinto

et al. 2021

Journal of Translational Autoimmunity

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Section: Helicobacter Pylori and Systemic Lupus Erythematosusmentioning

confidence: 99%

Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome

Etchegaray‐Morales

Jiménez-Herrera²,

Mendoza‐Pinto

et al. 2021

Journal of Translational Autoimmunity

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“…Previous studies reported maternal diabetes or chronic immune diseases are risk factors for congenital malformation or heart malformation . However, these patients have more frequent vaginal fungal infection compared with the general population and therefore those factors could be considered potential risk factors. However, these potential confounders were not consistent in each study.…”

Section: Discussionmentioning

confidence: 96%

The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta‐analysis

Zhang

Zhou

et al. 2019

BJOG

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Background Oral fluconazole is used to treat vulvovaginal candidiasis during pregnancy. However, there are concerns regarding the pregnancy outcomes following exposure to fluconazole.Objectives To evaluate the pregnancy outcomes associated with exposure to oral fluconazole during the first trimester of pregnancy.Search strategy A systematic literature search was conducted to identify relevant studies published from inception until April 2019.Selection criteria Relevant English-language citations using the terms oral fluconazole and pregnancy in humans.Data collection Two reviewers independently abstracted data and assessed study quality.Main results Oral fluconazole use during the first trimester of pregnancy was marginally associated with an increased risk of congenital malformations (odds ratio [OR] 1.09, 95% CI 0.99-1.2, P = 0.088; n = 6 studies), whereas in the subgroup analysis, this association existed only for high-dose users (>150 mg) (OR 1. 19, 95% CI 1.01-1.4, P = 0.039; n = 2). Exposure to fluconazole also increased the risk of heart malformations (OR 1.31, 95% CI 1.09-1.57, P = 0.003; n = 4), cardiac septal defects (OR 1.3, 95% CI 1.1-1.67, P = 0.047; n = 3), and tetralogy of Fallot (OR 3.39 95% CI 1.71-6.74, P < 0.001; n = 2) in the offspring. In addition, exposure to fluconazole was significantly associated with an increased risk of spontaneous abortion (OR 1.99, 95% CI 1.38-2.88, P < 0.001; n = 3).Conclusions Oral fluconazole use during the first trimester of pregnancy appears to be associated with heart malformations and spontaneous abortion, but a causal link cannot be proven.Tweetable abstract Oral fluconazole during the first trimester of pregnancy may be associated with unfavourable pregnancy outcomes.

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“…A recent study reported a higher incidence of mycoplasmas in the urogenital tract of women with SLE, but the difference was not statistically significant ( Alicja et al, 2020 ). Many previous studies have also claimed that patients with SLE have an increased likelihood of Ureaplasma urealyticum and Mycoplasma hominis infection, two genital mycoplasmas ( Machado et al, 2001 ; Mendez-Martinez et al, 2017 ). M. pneumoniae infection–induced SLE was not presented in these previous studies; thus, it needs further study to confirm its correlation.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma pneumonia Infection Is Associated With an Increased Risk of Systemic Lupus Erythematosus: A Nationwide, Retrospective Cohort Study

Chu

Hung

et al. 2022

Front. Microbiol.

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BackgroundInfections may play a role in the development of systemic lupus erythematosus (SLE).ObjectiveTo assess the link between Mycoplasma pneumonia (M. pneumonia) infection and the incidence of SLE.MethodWe conducted a retrospective cohort study, which identified 116,043 hospitalized patients with M. pneumoniae between 2000 and 2012 from the Taiwan National Health Insurance Research Database and compared them with 447,839 matched inpatients who had never been diagnosed with M. pneumonia infection (at a 1:4 ratio, matched by age, gender, and index year). Their comparative risk of developing SLE was evaluated. The follow-up period was defined as the time from the initial diagnosis of M. pneumonia infection to the date of SLE diagnosis, or December 31, 2013. The incidence rates of SLE were assessed in people with and without M. pneumoniae infection. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs), with the uninfected group used as the reference.ResultsThe adjusted HR of SLE for the M. pneumoniae group was 2.97 with 95% CI = 2.18–4.05 compared with the uninfected group. The risk was most significantly higher within 0.5 years after the M. pneumoniae infection with an adjusted HR of 6.18 (95% CI = 3.82–9.97, p < 0.01). The adjusted HR for SLE from 0.5 to 2 years and from 2 to 5 years after M. pneumoniae infection was 1.59 (95% CI = 0.70–3.59, p = 0.27) and 2.42 (95% CI = 1.22–4.81, p = 0.01), respectively.ConclusionThe incidence of SLE was significantly higher in subjects infected with M. pneumoniae.

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Genital Mycoplasma infection among Mexican women with systemic lupus erythematosus

Abstract: One-quarter of women with SLE had genital infection with U. urealyticum. An association was found between infection and multiparity among women with SLE.

Cited by 9 publications

References 24 publications

Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome

Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome

The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta‐analysis

Mycoplasma pneumonia Infection Is Associated With an Increased Risk of Systemic Lupus Erythematosus: A Nationwide, Retrospective Cohort Study

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