Genital Human Papillomavirus Infection

Tm, Becker; Km, Stone; Er, Alexander

doi:10.1016/s0889-8545(21)00062-0

Cited by 81 publications

(5 citation statements)

References 13 publications

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“…Solvents and other chemicals were reagent grade and used as received. 1 H-NMR spectra for analysis of synthesized compounds were recorded at 300 MHz and expressed as ppm downfield from tetramethylsilane (TMS) as an internal standard. Column chromatography was performed on Kiesel gel 60 silica (EM Science).…”

Section: Methodsmentioning

confidence: 99%

“…Papilloma viruses are a group of small DNA tumor viruses that infect a wide variety of mammalian cells. They are the causative agents of benign proliferative lesions of the skin or mucosa, and certain strains have been implicated in the development of cervical carcinomas and other malignancies. , All of the papillomaviruses encode a DNA-binding protein, E2, that regulates the transcription of several viral genes and, in conjunction with the E1 protein, is required for viral replication. − …”

Section: Introductionmentioning

confidence: 99%

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NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

et al. 1997

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The E2 protein is required for the replication of human papillomaviruses (HPVs), which are responsible for anogenital warts and cervical carcinomas. Using an NMR-based screen, we tested compounds for binding to the DNA-binding domain of the HPV-E2 protein. Three classes of compounds were identified which bound to two distinct sites on the protein. Biphenyl and biphenyl ether compounds containing a carboxylic acid bind to a site near the DNA recognition helix and inhibit the binding of E2 to DNA. Benzophenone-containing compounds which lack a carboxylic acid group bind to the beta-barrel formed by the dimer interface and exhibit negligible effects on the binding of E2 to DNA. Structure-activity relationships from the biphenyl and biphenyl ether compounds were combined to produce a compound [5-(3'-(3",5"-dichlorophenoxy)-phenyl)-2,4-pentadienoic acid] with an IC50 value of approximately 10 microM. This compound represents a useful lead for the development of antiviral agents that interfere with HPV replication and further illustrates the usefulness of the SAR by NMR method in the drug discovery process.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

et al. 1997

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“…G enital infection by the human papillomavirus (HPV) is more frequent in teenagers from 15 years on, with a maximum prevalence till 25 years approximately. Very unusual in childhood and after 60 years age (1,7,14). Data obtained both in Europe and United States of America suggest that during the last 20 years the HPV infections increased considerably, as well as other sexually transmitted diseases (7).…”

Section: Introductionmentioning

confidence: 99%

“…Data obtained both in Europe and United States of America suggest that during the last 20 years the HPV infections increased considerably, as well as other sexually transmitted diseases (7). Since 1982 a high increase in the infections diagnose has been experienced, based on the great number of cytologic, colposcope and histopathological examinations of the uterine coli injuries (1,7). According to Biro and Hillard (1990) the infection by HPV, even being frequent in teenagers, only 10% of the cases are symptomatic.…”

Section: Introductionmentioning

confidence: 99%

Infection by the human papillomavirus in teenagers sexually active: clinic and subclinic manifestations

et al. 1995

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This research studies the association of the cervical condyloma with the intraepithelial neoplasia, during sex activity, pregnancy, diagnose methods, cytology and colposcopy in teenagers. The objective of this research is to study the propaedeutics for the uterine coli condyloma diagnose in a group of teenagers. For this purpose, we have studied 131 teenagers sexually active with ages between 14 and 19 years and presenting histologically confirmed uterine coli condyloma. Association with intraepithelial neoplasia, sexual activity duration, method of diagnose, pregnancy analysis, cytology and colposcopy results and association with vulva and vagina injuries were evaluated. The high association rate with condyloma and intraepithelial neoplasia after a short time of sexual activity and the none presence of macroscopic warts in the genital organs in 80% of cases presenting cervical condyloma, demonstrate that: a more careful investigation with colposcopy and biopsy of the inferior genitals of the women-teenagers sexually active is needed, when presenting modified cervical cytology.

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“…Acredita-se que a infecção genital causada pelo papilomavírus seja a doença sexualmente transmissível mais comum nos dias de hoje e uma das razões freqüentes para visitas ao ginecologista (BECKER, STONE, ALEXANDER, 1987;SWYGART, 1997).…”

Section: Nt Roduçãounclassified

Avaliação de alguns fatores de risco femininos e masculinos no resultado da peniscopia dos parceiros sexuais de mulheres com infecção pelo papilomavirus humano

Tiago¹,

Bedone²

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Ao Prof. Dr. Jessé de Paula Neves Jorge " O homem erudito é um descobridor de fatos que já existem, mas o homem sábio é um criador de valores que não existem e que ele faz existir" . Exemplo de integridade moral e ética, exíminio contador de histórias. Por demonstrar que o verdadeiro valor do homem está no seu caráter. Ao Prof. Dr. Airton Rodrigues de Mello amigo, incentivador, colaborador na correção deste trabalho e um professor de inestimável senso e valor acadêmico. Ao Dr. Paulo Sérgio Alessi Bueno de Campos amigo, maior responsável pela minha formação cirúrgica e profissional. De inteligência suprema, criador de idéias e dicas fundamentais para execução deste trabalho e de minha vida pessoal. Ao Dr. Francisco Eduardo Prota por acreditar em nosso trabalho e sempre incentivar a nossa vida acadêmica. Grato pela amizade e palavras sempre positivas de estímulo e pelo tempo dedicado só para acrescentar Agradeciment os Aos docentes, médicos da Pontíficia Universidade Católica de Campinas que respeitaram os momentos de dificuldade sempre com afeto. Aos professores doutores, Renato Passini Júnior e Aurea Akemi Abe Cairo pela participação no exame de qualificação e pelas valiosas sugestações e correções. A Professoras Doutoras Arlete Maria dos Santos Fernandes e Ilza Maria Urbano Monteiro pela dedicação, carinho e apoio neste trabalho. Ao professor doutor, José Guilherme Cecatti pelos seus ensinamentos em metodologia científica e pôr suas palavras de constante incentivo. Ao Dr. Luís Fernando Franco Penteado por sua legítima amizade e por despertar um sorriso nos momentos mais difícies. As Dras. Diana Felip Raskin e Patricia Gadia da Silva Leme La Guardia pela amizade descompromissada e leal. Ao Dr. Paulo Sérgio Cossi pela amizade sincera, ajuda e disponibilidade persistente na elaboração deste trabalho. Aos Drs. Luís Henrique da Silva Leme e Júlio Cesar Narciso Gomes pela amizade, compreensão e apoio. Ao Dr. Maurício de Souza Arruda, pela amizade e incentivos constantes. Ao Sr. Edson L. Martinez pela maneira eficaz e pontual na elaboração da análise estatística deste trabalho.A Sra. Margarete Donadon pelo carinho, amizade, disponibilidade integral, senso de profissionalismo e atenção especial dispensada em todos momentos da execução deste trabalho.A Sra. Maria Regina Sousa Campos por sua zelosa participação e incentivo.Ao pessoal da ASTEC, em especial, a Sra. Fernanda Atibaia e Sra. Sueli Chaves pela integral atenção realizada na correção da íntegra deste trabalho.Aos médicos residentes e acadêmicos responsáveis pelo estímulo a necessidade contínua do aprendizado a minha eterna gratidão.

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Genital Human Papillomavirus Infection

Cited by 81 publications

References 13 publications

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Infection by the human papillomavirus in teenagers sexually active: clinic and subclinic manifestations

Avaliação de alguns fatores de risco femininos e masculinos no resultado da peniscopia dos parceiros sexuais de mulheres com infecção pelo papilomavirus humano

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