Genital gonorrhoea in women: A serovar correlation with concomitant rectal infection

Coghill, D.V.; Young, H

doi:10.1016/s0163-4453(89)91122-5

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…To achieve the full potential from serovar analysis, however, it is necessary to have accurate data on the serotype of all of the strains circulating within a given population. Whilst our initial studies (5) defined the serovar distribution of gonococci isolated in Edinburgh and identified particular serovars associated with male rectal (4) and female rectal (6) infections, serotyping of a small number of isolates from Glasgow (9) suggested that there may be marked geographical differences in the prevalence of certain serovars. This study was undetaken to examine the distribution of gonococcal serovars from centres within Greater Glasgow, Tayside, Fife and Lothian Health Board Areas, serving a total population of approximately 2 million (Fig.…”

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confidence: 99%

Gonococcal infection within Scotland: Antigenic heterogeneity and antibiotic susceptibility of infecting strains

et al. 1990

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Two panels of monoclonal antibody reagents were used to serotype all strains of Neisseria gonorrhoeae isolated from four separate geographical areas serving two million of the five million Scottish population. Serotype 1B isolates accounted for 60% of the 869 strains examined and were more prevalent than 1A isolates in each geographical area. A total of 11 1A serovars and 47 1B serovars were recognised. Only two of the 11 1A serovars (Aedgkih/Arost and Aedih/Arst) were found in every centre but these accounted for over 90% of the 1A isolates. Although there was a total of 47 different 1B serovars over 80% of the isolates were accounted for by the ten most commonly encountered serovars. There were, however, marked geographical differences within both major and minor serovars. There was a highly significant difference (P less than 0.001) between protein 1A and 1B serovars with respect to their susceptibility to penicillin. Within each protein 1 type there were also differences in antibiotic susceptibility. Penicillinase-producing N. gonorrhoeae (PPNG) were found in all centres and accounted for 24 (2.8%) of the 869 isolates. The majority of the PPNG (71%) were serotype 1A and with one exception were serovar Aedih/Arst. PPNG strains accounted for 37% (16) of the 43 Aedih/Arst isolates. Epidemiological, diagnostic and therapeutic implications arising from the distinct geographical differences in the pool of circulating gonococci are discussed.

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Section: Introductionmentioning

confidence: 99%

Gonococcal infection within Scotland: Antigenic heterogeneity and antibiotic susceptibility of infecting strains

et al. 1990

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“…auxotyping. The epidemiological applications include identifying associations between sexual orientation and serovar (4,18) and between site of infection and serovar (5). Certain serovars (1B-5/7 [8,16]) are associated with I Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Serotype patterns of gonococcal infection in contact pairs

et al. 1993

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The use of gonococcal serovars in studying the epidemiology of Neisseria gonorrhoeae is well established. Most studies assume that the isolated serovar remains stable in vivo indefinitely. This study was designed to observe the correlation between serovars isolated in patients naming each other as sexual contacts. The overall rate of discordant transmission episodes was 12% (26/220). There were however significantly more discordant transmission episodes for partners of patients infected with IB serovars than IA serovars: 19% (23/124) versus 3% (3/96) - p < 0.01. The overall prevalence of serogroup IB isolates although significantly higher at 53% (p < 0.01) was thought insufficient to account for the correlation between discordant pairs and serogroup IB infection. Reasons considered for the discrepancies in contact pairs included: problems of partner reporting involving inaccurate or incomplete information; technical problems with reagents; culture induced phenotypic variation in antigenic expression or differences in the in vitro recognition of epitopes; and antigenic differences resulting from genetic mutation within the Protein I gene. It was concluded that carefully planned and controlled prospective studies involving duplicate parallel testing of isolates from patients and their well documented partners are needed to assess the extent to which these various factors contribute to discordancies in serovars isolated from contact pairs. Serotyping should be combined with other methods such as auxotyping for detailed microepidemiological studies involving partner notification.

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Sexuell übertragbare Erkrankungen des Anorektums

Ochsendorf

Schöfer

Infektiologie Des Gastrointestinaltraktes

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Genital gonorrhoea in women: A serovar correlation with concomitant rectal infection

Cited by 6 publications

References 32 publications

Gonococcal infection within Scotland: Antigenic heterogeneity and antibiotic susceptibility of infecting strains

Gonococcal infection within Scotland: Antigenic heterogeneity and antibiotic susceptibility of infecting strains

Serotype patterns of gonococcal infection in contact pairs

Sexuell übertragbare Erkrankungen des Anorektums

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