Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis

Dias, Alyria Teixeira; Castro, Sandra Bertelli Ribeiro de; Alves, Caio César de Souza; Evangelista, Marcilene Gomes; Silva, Luan Cristian da; Reis, D. R. de L.; Machado, M. A.; Juliano, María A.; Ferreira, Ana Paula

doi:10.1007/s00011-018-1146-7

Cited by 13 publications

(5 citation statements)

References 50 publications

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“…On the other hand, although some TLRs have been shown to have detrimental effects in brain inflammation, other studies have reported that pattern recognition receptors, such as TLR3 can have important functions in ameliorating the progression of MS (Marta, 2009). In the EAE mouse model, TLR3 and TLR9 responses were found to be downregulated (Marta, 2009), and an activator of TLR3 rescued cellular infiltration in neuronal tissue and reduced demyelination (Evangelista et al, 2016; Dias et al, 2018). Interestingly, TLR3 has gained special attention because of its role in the control of HSV-1 infection of the CNS.…”

Section: Cns Inflammation Induced By Hsv-1mentioning

confidence: 99%

Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders

Duarte

Farías

Álvarez

et al. 2019

Front. Cell. Neurosci.

124

111

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Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain without evident clinical symptoms. Once in the central nervous system (CNS), the virus can either reside in a quiescent latent state in this tissue, or eventually actively lead to severe acute necrotizing encephalitis, which is characterized by exacerbated neuroinflammation and prolonged neuroimmune activation producing a life-threatening disease. Although HSV-1 encephalitis can be treated with antivirals that limit virus replication, neurological sequelae are common and the virus will nevertheless remain for life in the neural tissue. Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders. Here, we review and discuss acute and chronic infection of particular brain regions by HSV-1 and how this may affect neuron and cognitive functions in the host. We review potential cellular and molecular mechanisms leading to neurodegeneration, such as protein aggregation, dysregulation of autophagy, oxidative cell damage and apoptosis, among others. Furthermore, we discuss the impact of HSV-1 infection on brain inflammation and its potential relationship with neurodegenerative diseases.

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Section: Cns Inflammation Induced By Hsv-1mentioning

confidence: 99%

Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders

Duarte

Farías

Álvarez

et al. 2019

Front. Cell. Neurosci.

124

111

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“…It has been found that prophylactic oral treatment with Gen is capable to modulate the immune response and reduce the EAE severity, if initiated in the early stages of the disease, through increasing the expression of Toll‐like receptors (TLR3, TLR9) in dendritic cells and macrophages, and endogenous IFN‐β production in the spinal cord. These activate suppressor T‐cells and inhibit IL‐17 and IL‐23 production besides reducing the factors of Th1 and Th17 cells (Dias et al, 2018) (Figure 7). These findings support the previous outcomes obtained by Jahromi, Arrefhosseini, Ghaemi, Alizadeh, Sabetghadam, and Togha (2014) who reported that treating C57Bl/6 mice models of EAE with Gen reduced neuronal demyelination, suppressed the production of IFN‐γ and enhanced IL‐10 secretion in the brain during the early phases of the disease.…”

Section: Molecular Targets Of Phytoestrogen‐isoflavones In Neurodegen...mentioning

confidence: 99%

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Al‐Shami

Essawy

Elkader

2023

Phytotherapy Research

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Neurodegenerative disorders are heterogeneous, debilitating, and incurable groups of brain disorders that have common features including progressive degeneration of the structure and function of the nervous system. Phytoestogenic‐isoflavones have been identified as active compounds that can modulate different molecular signaling pathways related to the nervous system. The main aim is to shed the light on the molecular mechanisms followed by phytoestrogen‐isoflavones profound in the Trifolium pratense and discuss the latest pharmacological findings in the treatment of neurodegenerative disorders. Data were collected using different databases. The search terms used included “Phytoestrogens,” “Isoflavones,” “neurodegenerative disorders,” “Neuronal plasticity,” etc., and combinations of these keywords. As a result, this review article mainly demonstrates the potential neuroprotective properties of phystoestrogen‐isoflavones present in the Trifolium pratense (Red clover), particularly in neurodegenerative disorders. Phytochemical studies have shown that Trifolium pratense mainly includes more than 30 isoflavone compounds. Among them, phytoestrogen‐isoflavones, such as biochanin A, daidzein, formononetin, genistein (Gen), etc.,are characterized by potent neuroprotective properties against different neurodegenerative disorders. There are preclinical and clinical scientific evidence on their mechanisms of action involve molecular interaction with estrogenic receptors, anti‐inflammatory, anti‐oxidative, antiapoptotic, autophagic inducing, and so on. phytoestrogen‐isoflavones are the major bioactive components in the Trifolium pratense that exhibit therapeutic efficacy in the case of neurodegenerative disorders. This review provides detailed molecular mechanisms targeted by phytoestrogen‐isoflavones and experimental key findings for the clinical use of prescriptions containing Trifolium pratense‐derived isoflavones for the treatment of neurodegenerative disorders.

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“…98 IFN-β has a vital role in treating MS by decreasing the frequency of the relapses and the appearance of novel lesions. 99 Dias et al have demonstrated the genistein ability to moderate the involved factors in innate immune response in the EAE preliminary phase. The therapy with genistein delayed the disease resumption, with decreased inflammatory demyelination as well as infiltration.…”

Section: Animal Studiesmentioning

confidence: 99%

“…This study may show the genistein potential as a preventative strategy for preventing multiple sclerosis (MS). 99 Ohgomori et al figured out that GEN could act on mature oligodendrocytes in the hippocampus by increasing their myelin formation and survival and offer the phytoestrogens therapeutic possibility to treat MS patients who suffer from mental health problems. 100…”

Section: Animal Studiesmentioning

confidence: 99%

Pharmacotherapeutic potential of soy isoflavones in neurological disorders

Mokhtari¹,

Qolipour²,

Yousefi³

et al. 2022

NeuroAsia

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In specific populations, soy products have been a part of their diet for many centuries. Soybeans are known to be beneficial mostly because of being rich sources of isoflavones. Various studies showed that Soy isoflavones such as daidzein and genistein have positive effects on gastrointestinal health, cancer prevention, and health promotion in postmenopausal women. In recent years, many studies focused on the neuroprotective effects of soy isoflavones in animal models and humans. This review includes the latest literature on the effects of soy isoflavones in various neurological disorders. In conclusion, soy isoflavones have neuroprotective, anti-inflammatory, and anti-oxidant effects and can be used to prevent stroke, improve memory and cognitive function, reduction of Parkinson’s disease symptoms, and also as a therapeutic agent in multiple sclerosis.

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Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis

Abstract: These findings shed light on the potential of genistein as a prophylactic strategy for multiple sclerosis (MS) prevention.

Cited by 13 publications

References 50 publications

Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders

Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Pharmacotherapeutic potential of soy isoflavones in neurological disorders

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