Genistein: Its role in metabolic diseases and cancer

Mukund, Vidya; Mukund, Dhruv; Sharma, Vinay; Mannarapu, Mastan; Alam, Afroz

doi:10.1016/j.critrevonc.2017.09.004

Cited by 188 publications

(148 citation statements)

References 140 publications

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“…There are differences in the expression of estrogen receptors and the aromatase. Since the main role of GEN involves its interaction with estrogen receptors, the estrogenic effect is commonly reported in the investigations of GEN [52,56]. The current study showed that LGE treatment exerts estrogenic activity and promotes spermatogenesis in PND35 male mice, while HGE treatment causes incomplete spermatogenesis.…”

Section: Discussionsupporting

confidence: 55%

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Oral Exposure to Genistein during Conception and Lactation Period Affects the Testicular Development of Male Offspring Mice

Shi

et al. 2020

Animals

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Sexual hormones are essential for the process of spermatogenesis in the testis. However, the effect of maternal genistein (GEN) on the pups’ testicular development remain-unclear. Our present study evaluated the effects of supplementing GEN for parental and offspring mice on the reproductive function and growth performance of the male pups. Mothers during gestation and lactation period were assigned to a control diet (CON group), low dose GEN (LGE group) diet (control diet +40 mg/kg GEN), and high dose of GEN (HGE group) diet (control diet +800 mg/kg GEN). Their male offspring underwent the same treatment of GEN after weaning. LGE treatment (40 mg/kg GEN) significantly increased body weights (p < 0.001), testes weights (p < 0.05), diameters of seminiferous tubule (p < 0.001) and heights of seminiferous epithelium (p < 0.05) of offspring mice. LGE treatment also increased serum testosterone (T) levels and spermatogenesis scoring (p < 0.05). However, HGE treatment (800mg/kg GEN) significantly decreased body weights (p < 0.001), testes weights (p < 0.05) and testis sizes (p < 0.001). Furthermore, mRNA expressions of ESR2 (p < 0.05), CYP19A1 (p < 0.001), SOX9 (p < 0.001) and BRD7 (p < 0.001) in testis of mice were increased in the LGE group. Similarly, HGE treatment increased mRNA expressions of ESR2 (p < 0.05) and CYP19A1 (p < 0.001). However, mRNA expressions of SOX9 and BRD7 were decreased significantly in the HGE group (p < 0.001). Meanwhile, higher ratio apoptotic germ cells and abnormal sperms were detected in the HGE group (p < 0.001). In conclusion, exposure to a low dose of GEN during fetal and neonatal life could improve testicular development of offspring mice, whereas, unfavorable adverse effects were induced by a high dose of GEN.

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Section: Discussionsupporting

confidence: 55%

“…Sexual hormones, including testosterone, are indispensable for the process of spermatogenesis in the testis. GEN can affect testicular development by modulating steroidal hormone receptors [52]. As we all know, testosterone plays a pivotal role in the regulation of structure development of testis [53].…”

Section: Discussionmentioning

confidence: 99%

Oral Exposure to Genistein during Conception and Lactation Period Affects the Testicular Development of Male Offspring Mice

Shi

et al. 2020

Animals

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“…e present study showed that positive signals of p65 in various groups have the same tendency with the expressions of inflammatory mediators, which indicated that NF-κB phosphorylation may be induced by IL-1β and TNF-α in the TMJOA model. Genistein, which is known to have multiple molecular effects, such as the inhibition of inflammation, promotion of apoptosis, and modulation of metabolic pathways, plays an important role in preventing and treating common disorders [23]. Studies on positive effects of genistein have been reported in inflammatory disease.…”

Section: Discussionmentioning

confidence: 99%

“…Daily treatment was performed with genistein (99.5% pure; Winherb Med., China) and sterile saline by intragastric administration in GE1 (30 mg/kg), GE2 (180 mg/kg), NC (2 ml saline), and OA (2 ml saline) groups, respectively. Figure 1 showed the chemical structure of genistein [23].…”

Section: Model Buildingmentioning

confidence: 99%

Protective Effect of Genistein on Condylar Cartilage through Downregulating NF-κB Expression in Experimentally Created Osteoarthritis Rats

Jian

Ding

et al. 2019

BioMed Research International

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Temporomandibular joint osteoarthrosis (TMJOA) is characterised by chronic inflammatory changes, with subsequent gradual loss of joint cartilage. NF-κB is a crucial transcription factor in the course of inflammatory and immune responses, which are involved in OA pathology activated by proinflammatory cytokines. Genistein is known to have anti-inflammation and modulation of metabolic pathways through repression of the NF-κB signaling pathway in inflammatory disease. But so far, studies on the effects of genistein on TMJOA are very limited. So, the purpose of this study is to investigate the protective effect of genistein against experimentally induced condylar cartilage degradation through downregulating NF-κB expression in created osteoarthritis rats in vivo. Male SD rats were created as temporomandibular joint osteoarthritis models and administered through oral gavage with low and high dosage genistein (30 mg/kg and 180 mg/kg, respectively) daily for 4 weeks. The morphological changes of the condylar cartilage were studied with HE and Masson staining. The expressions of p65 and inflammatory cytokines (IL-1β and TNFα) were detected using immunohistochemistry and real-time PCR. The results showed that experimentally created osteoarthritis reduced the condylar cartilage thickness of rats and increased the gene expression of cytokines (IL-1β and TNFα) and positive cells of p65. Genistein treatment had positive effects on the condylar cartilage renovation, while high dose genistein treatment had more significant effects on the reversing of OA changes and reduction of the expression of p65 and inflammatory cytokines (IL-1β and TNFα). The results indicated that high dose genistein treatment had obvious therapeutic effects on condyle cartilage damages of OA rats. The mechanism may be that genistein suppresses the NF-κB expression activated by inflammatory cytokines.

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“…Genistein is known to have multiple molecular effects, such as the inhibition of inflammation, carcinogenesis, obesity, osteoporosis, and metabolic syndrome. [30] Furthermore, it has been reported to improve skin changes caused by aging. [31] Similar to quercetin and kaempferol, the amount of extracted genistein derivatives depended only on ethanol concentration as quadratic factor (Table 3).…”

Section: Quercetin Kaempferol and Genistein Derivativesmentioning

confidence: 99%

Optimization of Ultrasound-Assisted Extraction of Phenolic Antioxidants from Lotus corniculatus

Fumić

Jug

Končić

2019

Croat. chem. acta (Online)

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Ultrasound-assisted extraction of phenolic antioxidants from Lotus corniculatus was optimized using response surface methodology. The extraction was performed according to the Box–Behnken design with ethanol concentration, temperature, and pH, as independent variables. The responses were extraction yield, DPPH radical scavenging activity (RSA) IC50 and content of different phenolic compounds (total phenols, flavonoids and phenolic acids, as well as quercetin, kaempferol and genistein derivatives). The models were used to calculate best conditions for maximal extraction of phenolic compounds and antiradical activity. Use of the optimized extraction parameters increased the content of quercetin and kaempferol derivatives more than tenfold (from 6.07 to 65.10 mg mL–1 and 6.69 to 92.75 mg mL–1, respectively). The results of this work stress the importance of careful selection of conditions for flavonoids extraction. Abundance of bioactive phenolics in L. corniculatus extracts obtained under optimized extraction conditions opens the possibility for wider utilization of this plant.

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Genistein: Its role in metabolic diseases and cancer

Cited by 188 publications

References 140 publications

Oral Exposure to Genistein during Conception and Lactation Period Affects the Testicular Development of Male Offspring Mice

Oral Exposure to Genistein during Conception and Lactation Period Affects the Testicular Development of Male Offspring Mice

Protective Effect of Genistein on Condylar Cartilage through Downregulating NF-κB Expression in Experimentally Created Osteoarthritis Rats

Optimization of Ultrasound-Assisted Extraction of Phenolic Antioxidants from Lotus corniculatus

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