Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model

Ma, Xing; Yu, Xiaowei; Min, Jialing; Chen, Xin; Liu, Ren; Cui, Xin; Cheng, Jing; Xie, Mingyong; Diel, Patrick; Hu, Xiaojuan

doi:10.1016/j.toxlet.2021.11.013

Cited by 8 publications

(2 citation statements)

References 30 publications

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“…Notably, many of them represent food- or microbiome-derived metabolites that mostly accumulated in the tumors in presence of diabetes, whereas a small number of metabolites represent typical energy or tumor metabolism–related molecules (e.g., α-ketoglutarate, glucose). Food-derived metabolites include isoflavones like genistein and daidzein sulfate that may reduce the risk of breast cancer recurrence but may also interfere with the antitumor effects of breast cancer therapeutics ( 24 , 25 ). At least 8 of the 71 diabetes/hyperglycemia-associated metabolites have previously been linked to the gut microbiome ( 26 , 27 ) and included hippurate as the metabolite with the most significant accumulation, besides imidazole propionate, 3-phenylprorionate, or phenyl sulfate, among others ( Supplemental Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency

Panigrahi,

Candia,

Dorsey

et al. 2023

JCI Insight

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Diabetes commonly affects patients with cancer. We investigated the influence of diabetes on breast cancer biology using a 3-pronged approach that included analysis of orthotopic human tumor xenografts, patient tumors, and breast cancer cells exposed to diabetes/hyperglycemia-like conditions. We aimed to identify shared phenotypes and molecular signatures by investigating the metabolome, transcriptome, and tumor mutational burden. Diabetes and hyperglycemia did not enhance cell proliferation but induced mesenchymal and stem cell–like phenotypes linked to increased mobility and odds of metastasis. They also promoted oxyradical formation and both a transcriptome and mutational signatures of DNA repair deficiency. Moreover, food- and microbiome-derived metabolites tended to accumulate in breast tumors in the presence of diabetes, potentially affecting tumor biology. Breast cancer cells cultured under hyperglycemia-like conditions acquired increased DNA damage and sensitivity to DNA repair inhibitors. Based on these observations, we conclude that diabetes-associated breast tumors may show an increased drug response to DNA damage repair inhibitors.

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Section: Resultsmentioning

confidence: 99%

Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency

Panigrahi,

Candia,

Dorsey

et al. 2023

JCI Insight

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“…In the MCF-7 breast cancer cell line, high dose (100 μM) of genistein combined with the chemotherapeutic agent, cisplatin, suppressed breast cancer cell growth and proliferation, whereas 10 μM of genistein antagonized the action of cisplatin to induce cancer cell apoptosis [ 89 ]. Further investigation confirmed that oral genistein supplementation (5 mg/kg/day) for three weeks counteracted cisplatin chemotherapy in breast cancer-bearing mice [ 91 ]. The anti-cancer effect of these soy isoflavones (genistein in particular) therefore remains controversial due to insufficient evidence.…”

Section: Polyphenols To Reduce Oxidative Stress In Cancer Cachexiamentioning

confidence: 98%

Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia

Swiderski

Murphy

et al. 2022

Antioxidants

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Cancer cachexia is the progressive muscle wasting and weakness experienced by many cancer patients. It can compromise the response to gold standard cancer therapies, impair functional capacity and reduce overall quality of life. Cancer cachexia accounts for nearly one-third of all cancer-related deaths and has no effective treatment. The pathogenesis of cancer cachexia and its progression is multifactorial and includes increased oxidative stress derived from both the tumor and the host immune response. Antioxidants have therapeutic potential to attenuate cancer-related muscle loss, with polyphenols, a group of plant-derived antioxidants, being the most widely investigated. This review describes the potential of these plant-derived antioxidants for treating cancer cachexia.

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Dietary interventions and tumor response to chemotherapy in breast cancer: A comprehensive review of preclinical and clinical data

Dikeocha,

Wardill,

Coller

et al. 2024

Clinical Nutrition ESPEN

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Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model

Cited by 8 publications

References 30 publications

Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency

Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency

Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia

Dietary interventions and tumor response to chemotherapy in breast cancer: A comprehensive review of preclinical and clinical data

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