Genistein inhibits the proliferation of human choriocarcinoma cells via the downregulation of estrogen receptor-α phosphorylation at serine 118

Yuseran, Hariadi; Hartoyo, Edi; Nurseta, Tatit; Kalim, Handono

doi:10.1016/j.yclnex.2020.10.001

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…It inhibited the proliferation of cells by downregulating Ki-67 and decreasing the phosphorylated estrogen receptor-α level at serine-118 [39] Glioblastoma multiforme (GBM) cells inhibited in vitro and in vivo radiation induced invasion and migration by blocking the DNA-PKcs/Akt2/Rac1 pathway [40]…”

Section: Mode Of Action Reference Gall Bladder Cancer (Gbc)mentioning

confidence: 99%

Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

Gupta

Kumar³

et al. 2023

ChemistrySelect

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Genistein is a natural isoflavone and a phytoestrogen known to possess broad range of pharmacological properties specifically explored for anticancer effects. The compound is under clinical trials for different types of cancer treatment. Structural modification of genistein has been done to prepare analogs with improved anticancer potential and pharmaceutical properties. Also, novel formulations of genistein have been developed to further improve water solubility and bioavailability for better clinical effectiveness. In the present review, we have summarized the recent available literature on genistein anticancer effects along with mechanism of action and clinical trial studies, reported analogs and novel formulations developed for improving the anticancer efficacy of genistein during the period 2013–2022. Also, the structure activity relationship (SAR) study of reported genistein analogs is described. Further, articles published in this period showed that both genistein and its various derivatives exhibit promising potential for the development of effective chemotherapeutic agents against different types of cancer. Further, the present review will help the researchers in design and development of genistein formulation with desired drug profile.

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Section: Mode Of Action Reference Gall Bladder Cancer (Gbc)mentioning

confidence: 99%

Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

Gupta

Kumar³

et al. 2023

ChemistrySelect

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“…In another study by Yuseran et al, which was conducted in silico, the interactions between genistein and several related proteins were evaluated. It was concluded that the administration of genistein can increase the genomic activity of estrogen–endothelial nitric oxide synthase (eNOS) receptor complexes related to apoptosis, proliferation, and telomere activity (Yuseran et al., 2021). In another docking study by Youn, it was revealed that genistein interacted with important amino acid residues in β‐site amyloid precursor protein cleaving enzyme 1 (BACE1), such as ASN37, GLN73, and TRP76, through hydrogen bonding.…”

Section: Molecular Docking and Bioinformatics Analysis Of Genisteinmentioning

confidence: 99%

Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview

Nazari-Khanamiri

Ghasemnejad‐Berenji

2021

J Food Biochem

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Genistein is the simplest secondary metabolite in soybeans and belongs to a group of compounds called isoflavones. It is a phytoestrogen and it makes up more than 60% of soy isoflavones. Studies have shown the anti‐inflammatory, anti‐apoptotic, and anti‐angiogenic effects of genistein in addition to its modulatory effects on steroidal hormone receptors. In this review, we discuss the pharmacologic and therapeutic effects of genistein on various diseases. Practical applications In this review, we have discussed the therapeutic effects of genistein as the main constituent of soybeans on health conditions. Its antioxidant, anti‐inflammatory, anti‐apoptotic and, anti‐angiogenic effects need more attention. The pharmacological properties of genistein make this natural isoflavone a potential treatment for various diseases such as postmenopausal symptoms, cancer, bone, brain, and heart diseases. Special emphasis should be given to it, resulting in using it in clinical as a safe, potent, and bioactive molecule.

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“…1). These actions include anti-inflammatory [51,52], antifungal [53], antitubercular [54,55], anticonvulsant [56], antimicrobial [57,58], anticancer [59][60][61], cholecystokinin-1 receptor antagonist, angiotensin-converting enzyme (ACE) inhibition [62,63], estrogen receptor (ER) ligand activity [64,65] and more.…”

Section: Introductionmentioning

confidence: 99%

Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review

Vashisht,

Sethi,

Bansal

et al. 2024

ajc

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Pyrazoles, a class of heterocyclic compounds, have garnered considerable attention in drug development due to their intriguing properties, particularly those containing a pyrazole moiety. Pyrazole, a pivotal chemical in the creation of potent bioactive agents, encompasses five heterocyclic members. The discovery of certain pyrazole compounds exhibiting robust biological activities has spurred interest in this field of inquiry. Heterocyclic compounds incorporating nitrogen and its derivatives have historically served as crucial sources of medicinal compounds. Given that the heterocyclic group constitutes a vast reservoir of organic molecules, its significance in both theoretical and applied chemistry has grown significantly. Extensive literature indicates that researchers have employed diverse synthetic strategies in recent years to produce substituted pyrazole derivatives with promising biological potential as anti-HIV, anti-inflammatory, antitumor and antimicrobial agents. Inflammation, a multifaceted biological response essential for the body’s defense mechanisms, can also contribute to various pathological conditions when dysregulated. Understanding the underlying molecular mechanisms offers a foundation for targeted interventions against inflammatory disorders. These insights fuel ongoing endeavors to discover effective and innovative anti-inflammatory agents with potential therapeutic applications. This review delves into the synthesis and characterization of various pyrazole derivatives, emphasizing structural modifications influencing their anti-inflammatory efficacy. The insights provided herein are invaluable for the rational design and synthesis of novel anti-inflammatory agents. Furthermore, the review concludes with a discussion on future perspectives, underscoring the imperative for further research to optimize the therapeutic potential of pyrazole derivatives as anti-inflammatory agents.

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Genistein inhibits the proliferation of human choriocarcinoma cells via the downregulation of estrogen receptor-α phosphorylation at serine 118

Cited by 4 publications

References 38 publications

Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview

Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review

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