Genistein inhibits the growth of human‐patient BPH and prostate cancer in histoculture

Geller, Jack; Sionit, Lida; Partido, Christine; Li, Lingna; Tan, Xiuying; Youngkin, Tyler; Nachtsheim, Daniel A.; Hoffman, Robert M.

doi:10.1002/(sici)1097-0045(19980201)34:2<75::aid-pros1>3.3.co;2-g

Cited by 24 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to studies in immortalized prostate cell lines, as discussed above, there is evidence to suggest an inhibitory effect of genistein on the growth of human-patient benign prostatic hypertrophy and prostate cancer tissue as well, at doses ranging from 1.25 to 10 μg/ml (27). A number of other studies support an effect of isoflavones against prostate cancer cell lines, and a detailed discussion is beyond the scope of this article.…”

Section: Cell Line Studiesmentioning

confidence: 92%

Perspectives on the Role of Isoflavones in Prostate Cancer

Ahmad

Biersack

et al. 2013

AAPS J

View full text Add to dashboard Cite

Abstract. Isoflavones have been investigated in detail for their role in the prevention and therapy of prostate cancer. This is primarily because of the overwhelming data connecting high dietary isoflavone intake with reduced risk of developing prostate cancer. A number of investigations have evaluated the mechanism(s) of anticancer action of isoflavones such as genistein, daidzein, biochanin A, equol, etc., in various prostate cancer models, both in vitro and in vivo. Genistein quickly jumped to the forefront of isoflavone cancer research, but the initial enthusiasm was followed by reports on its contradictory prometastatic and tumor-promoting effects. Use of soy isoflavone mixture has been advocated as an alternative, wherein daidzein can negate harmful effects of genistein. Recent research indicates a novel role of genistein and other isoflavones in the potentiation of radiation therapy, epigenetic regulation of key tumor suppressors and oncogenes, and the modulation of miRNAs, epithelial-to-mesenchymal transition, and cancer stem cells, which has renewed the interest of cancer researchers in this class of anticancer compounds. This comprehensive review article summarizes our current understanding of the role of isoflavones in prostate cancer research.

show abstract

Section: Cell Line Studiesmentioning

confidence: 92%

Perspectives on the Role of Isoflavones in Prostate Cancer

Ahmad

Biersack

et al. 2013

AAPS J

View full text Add to dashboard Cite

show abstract

“…Genistein inhibited the growth and induced apoptosis in LNCaP, DU-145 and PC3 prostatic cancer cells in a concentration p20 mM. [34][35][36][37][38][39][40][41][42] Genistein blocked the cell cycle progression at G 1 , inhibited PSA expression and modulated cell cycle gene regulation. 37,38,40,43 Expression of telomerase reverse transcriptase, c-myc mRNA and the MDM2 oncogene were downregulated by genistein, whereas p21 mRNA increased in response to genistein in PCa cells DU-145 and LNCaP.…”

Section: In Vitro Effects Of Phytoestrogensmentioning

confidence: 99%

Soy isoflavone genistein in prevention and treatment of prostate cancer

Perabo

Löw

Ellinger

et al. 2007

Prostate Cancer Prostatic Dis

115

View full text Add to dashboard Cite

“…6 Evidence that genistein is capable of inhibiting the human prostate growth was provided by a recent study on the histoculture of minced, surgically resected prostate tissue from men with benign prostatic hyperplasia. 7 In this model 2 to 4 M. of genistein caused a 50% inhibition of DNA synthesis. It has also been shown that genistein not only inhibits the growth of rat prostate adenocarcinoma cells in culture (22 M. IC 50 ), but also subcutaneously administered genistein inhibits the growth of rat adenocarcinoma cells injected in the flanks of Lobund-Wistar rats.…”

mentioning

confidence: 98%

The Effect of Isolated Soy Protein on Plasma Biomarkers in Elderly Men With Elevated Serum Prostate Specific Antigen

et al. 2001

View full text Add to dashboard Cite

Purpose: We performed a randomized double-blind crossover pilot study in elderly men with elevated prostate specific antigen (PSA) on the effects of the daily consumption of 2 soy beverages, each containing 20 gm. of isolated soy protein, on the isoflavone concentration in blood and urine, and on the 3 serum biomarkers cholesterol, PSA and the soluble p105 component of the p185erbB-2 proto-oncogene.Materials and Methods: A total of 34 men supplemented their diet by consuming 1 of 2 soy protein beverages assigned randomly twice daily for a 6-week period. In a second 6-week period they consumed the other soy protein beverage. The beverage ISPϩ provided 42 mg. of genistein and 27 mg. of daidzein daily, whereas the other beverage, ISPϪ, provided only 2.1 and 1.3 mg. of these isoflavones daily, respectively. Blood and 24-hour urine samples were obtained before the study, at 2-week intervals during the study and 2 weeks after study completion.Results: ISPϩ and to a lesser extent ISPϪ substantially increased the serum concentration and urinary output of the isoflavones and their metabolites. Serum cholesterol was significantly decreased by ISPϩ irrespective of the order in which the 2 soy beverages were administered and in apparent correlation with the total isoflavone concentration. There was no significant effect of the soy beverages on serum PSA and p105erbB-2 values.Conclusions: This study reveals that short-term exposure of elderly men with elevated serum PSA values to soy protein containing isoflavones decreases serum cholesterol but not the serum biomarkers PSA and p105erbB-2.KEY WORDS: prostate, prostate-specific antigen, soy proteins, biological markers, isoflavones Carcinoma of the prostate is a major health problem in American men. In 1998 there were more than 184,500 newly diagnosed cases and more than 39,000 deaths.1 Because there is no curative therapy for advanced prostate cancer, recent interest has focused on prostate cancer prevention. Several lines of evidence imply that dietary alterations in American men may decrease the risk for and incidence of prostate cancer. While it has been speculated that a diet with less than 30% fat may result in a decreased risk of prostate cancer, others believe that compliance with such a low fat diet would be poor. Other epidemiological studies indicate that the level of dietary soy consumption may be linked to a decreased risk of prostate cancer.2, 3 Soy contains large quantities of the isoflavone genistein (5,7,4í-trihydroxyisoflavone), a compound that is not present in other parts of the American diet ( fig. 1). 4 Men in southeast Asia, who consume 20 to 50-fold more soy daily than American men, have a 10-fold lower incidence of clinically significant prostate cancer and prostate cancer related death. 5,6 Thus, it has been hypothesized that American men may decrease the risk of prostate cancer by altering their diet to consume a higher level of soy proteins and, hence, genistein. 6Evidence that genistein is capable of inhibiting the human prostate growth wa...

show abstract

Genistein inhibits the growth of human‐patient BPH and prostate cancer in histoculture

Cited by 24 publications

References 0 publications

Perspectives on the Role of Isoflavones in Prostate Cancer

Perspectives on the Role of Isoflavones in Prostate Cancer

Soy isoflavone genistein in prevention and treatment of prostate cancer

The Effect of Isolated Soy Protein on Plasma Biomarkers in Elderly Men With Elevated Serum Prostate Specific Antigen

Contact Info

Product

Resources

About