Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

Palacios‐González, Berenice; Vargas‐Castillo, Ariana; Velázquez-Villegas, Laura A.; Vasquez-Reyes, Sarai; López, Patricia; Noriega, Lilia G.; Alemán, Gabriela; Tovar‐Palacio, Claudia; Torre-Villalvazo, Iván; Yang, Lijun; Zarain‐Herzberg, Ángel; Torres, Nimbe; Tovar, Armando R.

doi:10.1016/j.jnutbio.2019.03.012

Cited by 41 publications

(39 citation statements)

References 49 publications

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“…Genistein may induce the browning phenotype by a direct upregulation of Ucp1 expression or through an indirect pathway that would imply irisin signaling. Irisin is a myokine that induces the expression of Ucp1 and Tmem26 in preadipocytes [ 325 ]. This indirect mechanism describes an induction of the PGC-1α/FNDC5 pathway in skeletal muscle that lead to an increase of irisin production and secretion [ 325 ].…”

Section: Isoflavonesmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Section: Isoflavonesmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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“…Probably the nutraceuticals that have been most studied as modulators of irisin expression are polyphenols. In mice fed with genistein, an important isoflavone, browning process is facilitated by increasing of irisin concentrations [154]. Additionally, Kheiripour et al irisin improving metabolic condition in the liver of diabetic rats [155].…”

Section: Irisin: Nutritional Interventionsmentioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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“…Among the compounds that have been shown to increase AMPK activity is genistein, an isoflavone present in some foods, particularly in soy 10. Studies in rat skeletal muscle and adipose tissue show that phosphorylation of AMPK by genistein is accompanied by an increase in the expression of genes involved in fatty acid oxidation and also an increase in energy expenditure 11 12. In addition, C2C12 myotubes incubated with genistein have a greater capacity to oxidize palmitate 12…”

Section: Introductionmentioning

confidence: 99%

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects

Guevara‐Cruz

Godinez-Salas

Sánchez‐Tapia

et al. 2020

BMJ Open Diab Res Care

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ObjectiveObesity is associated with metabolic abnormalities, including insulin resistance and dyslipidemias. Previous studies demonstrated that genistein intake modifies the gut microbiota in mice by selectively increasing Akkermansia muciniphila, leading to reduction of metabolic endotoxemia and insulin sensitivity. However, it is not known whether the consumption of genistein in humans with obesity could modify the gut microbiota reducing the metabolic endotoxemia and insulin sensitivity.Research design and methods45 participants with a Homeostatic Model Assessment (HOMA) index greater than 2.5 and body mass indices of ≥30 and≤40 kg/m2 were studied. Patients were randomly distributed to consume (1) placebo treatment or (2) genistein capsules (50 mg/day) for 2 months. Blood samples were taken to evaluate glucose concentration, lipid profile and serum insulin. Insulin resistance was determined by means of the HOMA for insulin resistance (HOMA-IR) index and by an oral glucose tolerance test. After 2 months, the same variables were assessed including a serum metabolomic analysis, gut microbiota, and a skeletal muscle biopsy was obtained to study the gene expression of fatty acid oxidation.ResultsIn the present study, we show that the consumption of genistein for 2 months reduced insulin resistance in subjects with obesity, accompanied by a modification of the gut microbiota taxonomy, particularly by an increase in the Verrucomicrobia phylum. In addition, subjects showed a reduction in metabolic endotoxemia and an increase in 5′-adenosine monophosphate-activated protein kinase phosphorylation and expression of genes involved in fatty acid oxidation in skeletal muscle. As a result, there was an increase in circulating metabolites of β-oxidation and ω-oxidation, acyl-carnitines and ketone bodies.ConclusionsChange in the gut microbiota was accompanied by an improvement in insulin resistance and an increase in skeletal muscle fatty acid oxidation. Therefore, genistein could be used as a part of dietary strategies to control the abnormalities associated with obesity, particularly insulin resistance; however, long-term studies are needed.

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Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

Cited by 41 publications

References 49 publications

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects

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