Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

Kohara, Yumi; Kawaguchi, Shinichiro; Kuwahara, Rika; Uchida, Yasuzo; Oku, Yushi; Yamashita, Kimihiro

doi:10.1016/j.physbeh.2014.12.005

Cited by 18 publications

(6 citation statements)

References 39 publications

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“…GS can effectively protect neuron apoptosis induced by aβ in vitro [ 12 ]. However, GS can only play a limited role in cognitive recovery and memory improvement in vivo [ 13 ]. This is attributed to its extremely poor aqueous solubility (5.3 μM), low oral bioavailability, poor brain accumulation and lack of mitochondrial targeting [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

Yang

Gao²,

Wang³

et al. 2021

Bioactive Materials

112

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Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species (ROS) is an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic factor in the progression of AD. The targeted delivery of the antioxidants to mitochondria of injured neurons in brain is a promising therapeutic strategy for AD. A safe and effective drug delivery system (DDS) which is able to cross the blood-brain barrier (BBB) and target neuronal mitochondria is necessary. Recently, bioactive materials-based DDS has been widely investigated for the treatment of AD. Herein, we developed macrophage (MA) membrane-coated solid lipid nanoparticles (SLNs) by attaching rabies virus glycoprotein (RVG29) and triphenylphosphine cation (TPP) molecules to the surface of MA membrane (RVG/TPP-MASLNs) for functional antioxidant delivery to neuronal mitochondria. According to the results, MA membranes camouflaged the SLNs from being eliminated by RES-rich organs by inheriting the immunological characteristics of macrophages. The unique properties of the DDS after decoration with RVG29 on the surface was demonstrated by the ability to cross the BBB and the selective targeting to neurons. After entering the neurons in CNS, TPP further lead the DDS to mitochondria driven by electric charge. The Genistein (GS)- encapsulated DDS (RVG/TPP-MASLNs-GS) exhibited the most favorable effects on reliveing AD symptoms in vitro and in vivo by the synergies gained from the combination of MA membranes, RVG29 and TPP. These results demonstrated a promising therapeutic candidate for delaying the progression of AD via neuronal mitochondria-targeted delivery by the designed biomimetic nanosystems.

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Section: Introductionmentioning

confidence: 99%

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

Yang

Gao²,

Wang³

et al. 2021

Bioactive Materials

112

View full text Add to dashboard Cite

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“…Miso contains flavonoids, which are suggested to have benefits for physical health. For instance, flavonoids are thought to prevent cardiac disease, cancer, and osteoporosis [ 16 ], and to promote brain function, cognitive function, and learning and memory [ 17 ]. Green tea is rich in catechins, which are anti-oxidants and may help with glucose control [ 18 ], maintenance of cardiovascular function [ 19 ], and improvements in fat levels and blood pressure [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Mediators of the effects of rice intake on health in individuals consuming a traditional Japanese diet centered on rice

et al. 2017

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Although the Japanese diet is believed to be balanced and healthy, its benefits have been poorly investigated, especially in terms of effects on mental health. We investigated dietary patterns and physical and mental health in the Japanese population using an epidemiological survey to determine the health benefits of the traditional Japanese diet. Questionnaires to assess dietary habits, quality of life, sleep quality, impulsivity, and depression severity were distributed to 550 randomly selected middle-aged and elderly individuals. Participants with any physical or mental disease were excluded. Two-hundred and seventy-eight participants were selected for the final statistical analysis. We determined rice to be one of the most traditional foods in Japanese cuisine. Scores for each questionnaire were computed, and the correlations between rice intake and health indices were assessed. When analyzing the direct correlations between rice intake and health indices, we found only two correlations, namely those with quality of life (vitality) and sleep quality. Path analysis using structural equation modeling was performed to investigate the association between rice intake and health, with indirect effects included in the model. Additional associations between rice intake and health were explained using this model when compared to those using direct correlation analysis. Path analysis was used to identify mediators of the rice-health association. These mediators were miso (soybean paste) soup, green tea, and natto (fermented soybean) intake. Interestingly, these mediators have been major components of the Japanese diet since 1975, which has been considered one of the healthiest diets since the 1960s. Our results indicate that the combination of rice with other healthy foods, which is representative of the traditional Japanese diet, may contribute to improvements in physical and mental health.

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“…[231] Oral administration of genistein (1 and 10 mg/kg/day) in male Sprague dawley rats reported to exert improved cognitive functions in glucose loaded rats at the time of memory consolidation. [232] Lephart et al [233] were granted a patent on role of equol in mitigating a neuropsychiatric or neurodegenerative disease or disorder in a subject. Although many studies described about the positive aspect of SI in improving cognitive functions; [234,235] however, there are still some contradictory studies.…”

Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

Soy Bioactive Components in Functional Perspective: A Review

Garg

Lule

Malik

et al. 2016

International Journal of Food Properties

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Functional foods are the focus of attraction for well-being. The healthy living of Asians may be attributed to a diet enriched with soy isoflavones viz. genistein and daidzein which fills the gap of proteinaceous diet in vegetarians. Several factors, such as administration, dosage, metabolism, ingestion of other pharmacological substances, type of estrogen receptors, and presence or absence of endogenous estrogen, affect the activities and bioavailability of isoflavones. The mode of therapeutic action could be either through the stimulation of estrogen receptors or by the non-involvement of estrogen receptors. Soy, due to its isoflavones content, serves as a balanced and remedial substitute in combating various lifestyle disorders, like cancer prevention, by interruption of the breakdown of extracellular matrix that surrounds growing vessels and tumors, lowering of lipid and blood insulin levels by regulating lipid and glucose metabolism, alleviation of menopausal symptoms, and osteoprotective effects by modulating estrogen receptors, thus acting as a safer switch to hormone replacement therapy, anti-hypertensive effect which may also contribute to cardioprotective, anti-oxidative effect, regulation of cognitive functions, and many others. Therefore, it could be regarded as a valuable therapeutics. However, since soy isoflavones also act as endocrine disruptors, they also possess some negative effects. Concerns have been raised in relation to thyroid function abnormality. In view of the previously mentioned facts an attempt has been made to review the literature available on both beneficial as well as deleterious role of isoflavones, soy derived bioactive compounds.

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Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

Cited by 18 publications

References 39 publications

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

Mediators of the effects of rice intake on health in individuals consuming a traditional Japanese diet centered on rice

Soy Bioactive Components in Functional Perspective: A Review

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