Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway

Fan, Panhong; Fan, Shujun; Wang, Huan; Murata, Jun; Yu, Shaojun; Ibrahim, Mohammed Mohammed; Ma, Wei; Yu, Xiaotang; Hou, Zhengxin; Wang, Bo; Li, Lianhong

doi:10.1186/scrt357

Cited by 107 publications

(85 citation statements)

References 26 publications

(35 reference statements)

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“…Thus, genistein, a predominant isoflavone found in soy products, has been reported to decrease the CD44/CD24-positive CSC population in MCF7 breast tumor cells and mammosphere formation by downregulating Hedgehog-Gli1 signaling pathway (Fan et al, 2013). Acting on the same signaling pathway in prostate cancer, genistein was shown to suppress prostatosphere and colony formation in vitro and tumorigenicity in vivo (Zhang et al, 2012a).…”

Section: Anticancer Activity Of Polyphenol: Modulation Of Cell Redox mentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of polyphenols, a class of natural products widely explored for a potential applicability for the treatment of different diseases including cancer. While possessing interesting anticancer properties, polyphenols suffer from low stability and unfavorable pharmacokinetics, and thus suitable carriers are required when planning a therapeutic protocol. In the present review, an overview of the different strategies based on polymeric materials is presented, with the aim to highlight the strengths and the weaknesses of each approach and offer a platform of ideas for researchers working in the field.

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Section: Anticancer Activity Of Polyphenol: Modulation Of Cell Redox mentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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“…이소플라본은 식품 내 주요 기능성 물질 중 하나 로서 지속적인 주목을 받아 왔고, 섭취 시 남성 성기능에 악 영향을 미치지 않으며 (Mitchell et al, 2001;Dabrowski & Waldemar, 2004), 여성의 유방암에는 긍정적 효과가 있다 고 연구 (Yamamoto et al, 2003;Guha et al, 2009;Liu et al, 2012;Fan et al, 2013;Chen et al, 2014 …”

Section: 있고 이소플라본으로 명명되는 식물유래 여성호르몬(Phyto-unclassified

Effect of Thermal Treatments on Flavonoid Contents in Domestic Soybeans

Shin¹,

Kim²,

Lee³

et al. 2015

Korean Journal of Environmental Agriculture

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BACKGROUND: Soy isoflavones, structurally similar to endogenous estrogens, may affect human body through both hormonally mediated and non-hormonally related mechanisms. Heat processing could change chemical compositions. The effects of different thermal processes, boiling and HTHP(high temperature and high pressure) on the composition of isoflavone compounds and total amount of domestic soybeans were investigated in this study. METHOD AND RESULTS: Three different kinds of soybean samples were collected from RDA-Genebank. The samples were extracted using methanol, distilled water, and formic acid based solvent. Also the same solvents were used for mobile phase in UPLC/ToF/MS. All of the isoflavone compounds were analyzed based on the aglycone type of external standard for quantification. The standard calibration curve presented linearity with the correlation coefficient R2 > 0.98, analysed from 1 to 50 ppm

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“…8 While genistein has been reported to have a radioprotective effect on normal tissues, 9 treatment of non-inflammatory breast cancer cells with high doses (µM range) of genistein has been shown to increase radiation induced death through modulation of cell cycle and reduced expression of DNA repair proteins. 10 Although treatment of cancer cells with high doses of genistein may have a growth inhibitory effect, dietary intake may result in long term exposure to much lower doses.…”

Section: Introductionmentioning

confidence: 99%

Long Term, Low Dose Genistein decreases Stem Cell Populations and Sensitizes Inflammatory Breast Cancer Cell Lines to Radiation

Sims‐Mourtada

Opdenaker²,

Davis³

et al. 2015

Cancer Stud Mol Med Open J

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Short CommunicationPage 60 ABSTRACTLocal recurrence in inflammatory breast cancer is common and is associated with poor prognosis. Recurrence is driven by a small population of radioresistant breast cancer cells that have stem-like properties. Previous studies have shown that high doses of the soy isoflavone genistein have a growth inhibitory effect on tumor cells, and may sensitize non-inflammatory breast cancer cells to radiation. The objective of this study was to determine the effect of genistein on the growth and radioresistance of inflammatory breast cancer cells. We show that short-term treatment of inflammatory cell lines IBC3 and SUM149 with genistein decreases cell proliferation and mammosphere forming ability only at micromolar doses, but had minimal effect on stem cell marker expression and radioresistance of these cells. However, long term treatment with a low dose (nM) of genistein, which may mimic dietary intake, decreased stem cell populations and mammosphere forming ability and increased radiation, induced cell death in these lines. We propose that dietary intake of genistein may be associated with improved local response to treatment in inflammatory breast cancer by decreasing growth of breast cancer stem cells.

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Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway

Cited by 107 publications

References 26 publications

Polyphenols delivery by polymeric materials: challenges in cancer treatment

Polyphenols delivery by polymeric materials: challenges in cancer treatment

Effect of Thermal Treatments on Flavonoid Contents in Domestic Soybeans

Long Term, Low Dose Genistein decreases Stem Cell Populations and Sensitizes Inflammatory Breast Cancer Cell Lines to Radiation

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