Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review

Mazumder, Md. Anisur Rahman; Hongsprabhas, Parichat

doi:10.1016/j.biopha.2016.05.023

Cited by 117 publications

(54 citation statements)

References 105 publications

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“…Genistein (4', 5, 7-trihydroxyisoflavone), a soybean isoflavone, has been reported to possess anti-inflammatory, anti-oxidative, anti-diabetic, anti-cancer and estrogenic properties (Rahman & Hongsprabhas, 2016;Hussain & Green, 2017). Extensive epidemiology studies (Zhuo, Melby, & Watanabe, 2004;Li, Liu, Wang, Zhao, & Feng, 2016) and animal studies (Rosier & Saes, 2006;Sbarouni, Iliodromitis, Zoga, Theodorakis, & Kremastinos, 2007) have shown that genistein can significantly decrease plasma LDL-C, TC, total triglycerides, as well as homocysteine levels, and also increase plasma HDL-C levels, which improves endothelial function and reduces the risk factors of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Zheng

Yin

et al. 2019

Journal of Food Science

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It has been reported that genistein could improve metabolic syndromes. Our study aimed to investigate the effects and potential mechanisms of genistein on improving cholesterol metabolism in HepG2 cell. HepG2 cells were cultured with 0, 0.01, 1.00, 10.00, and 50.00 µM genistein for 24 hr. The current results showed a dose‐dependent manner between genistein and intracellular contents of total cholesterol (TC), high‐density lipoprotein‐cholesterol (HDL‐C), and cellular apolipoprotein A1 (Apo‐A1) secretion. TC was increased by 25.69%, meanwhile HDL‐C and Apo‐A1 were decreased by 56.00% and 25.93%, respectively, when the dosage of genistein was 1.00 µM. Genistein dose‐dependently upregulated the protein and mRNA levels of sterol regulatory element binding proteins‐2 (SREBP‐2), as well as the mRNA levels of low‐density lipoprotein receptor (LDLR) and 3‐hydroxy‐3‐methyl glutaryl coenzyme A reductase (HMGCR), by 145.91%, 72.29%, 310.23%, and 123.08%, respectively, when we gave 1.00 µM genistein, indicating that intracellular cholesterol synthesis and absorption of exogenous cholesterol were increased. In addition, the mRNA levels of peroxisome proliferator‐activated receptor‐γ (PPARγ) and liver X receptor (LXRα), lowered by 58.23% and 34.86% at 0.01 µM genistein, were reduced in a dose‐dependent manner. LXRα and ATP‐binding cassette transporter A1 (ABCA1) protein levels were significantly (P < 0.05) decreased by 50.35% and 11.60% at 1.00 µM genistein, which indicated that cellular cholesterol efflux was inhibited. Taken together, our results suggested that genistein at dosage of more than 1.00 µM was able to increase the intracellular cholesterol levels by up regulating SREBP‐2/LDLR/HMGCR pathway and suppressing PPARγ/LXRα/ABCA1 pathway. Practical Application In this study, genistein appeared to be effective in reducing plasma cholesterol levels due to increase the intracellular cholesterol levels by upregulating cholesterol absorption through SREBP‐2/LDLR/HMGCR pathway, and also downregulating cholesterol efflux via PPARγ/LXRα/ABCA1 pathway in vitro. In addition, plasma cholesterol is regarded as the key indicator of atherosclerosis; therefore, we believe that our findings could be used for further exploration on a possible therapeutic application of genistein for atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Zheng

Yin

et al. 2019

Journal of Food Science

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“…Let us discuss the subject from the viewpoints of activities of polyphenols and Th1/ Th2 differentiation. Other than nobiletin, the polyphenols quercetin and genistein have been shown to be potent antioxidants (20,21). How do these polyphenols regulate Ag-specific immune responses?…”

Section: Resultsmentioning

confidence: 99%

Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin

Nakamoto

Mitani

Urayama

et al. 2019

J Nutr Sci Vitaminol

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We examined the effect of nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) on immune response in ovalbumin (OVA)-immunized mice. Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production. In addition, mice that received nobiletin showed higher levels of OVA-specific IgE, IgG and IgG1 production than did control mice. The antibody response to the thymus-independent antigen 2,4,6-trinitrophenyl-Ficoll was not different in the control and nobiletin groups, suggesting that nobiletin does not directly stimulate antibody production. An in vitro study showed that treatment with nobiletin enhanced the ability of antigen presentation of bone marrow-derived dendritic cells. The in vivo and in vitro results indicate that nobiletin regulates immune function.

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“…Curcumin as a powerful antioxidant has radioprotective effect on normal cells [30], while it has radiosensitizing effect in tumor cells by increasing ROS level and suppressing inflammatory process such as NF-κΒ activation pathway induced by ionizing radiation [31][32][33]. Genestein has antioxidant activity and protect healthy cell against toxicity induced by IR [34,35]. Genistein stimulated irradiation-induced intracellular reactive oxygene and suppressed irradiation-induced COX-2 expression, as an inflammation marker, resulted in radiosensitizing effect in cancerous cells [36].…”

Section: Discussionmentioning

confidence: 99%

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Azizi¹,

Ghasemi²,

Asgarian-Omran³

et al. 2018

mpj

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Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

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Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review

Cited by 117 publications

References 105 publications

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

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