Genistein ameliorates inflammation and insulin resistance through mediation of gut microbiota composition in type 2 diabetic mice

Yang, Rui; Jia, Qiang; Mehmood, Shomaila; Ma, Shanfeng; Liu, Xiaofen

doi:10.1007/s00394-020-02403-0

Cited by 54 publications

(41 citation statements)

References 45 publications

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“…Daidzein and genistein suppressed gluconeogenic enzyme activity in the liver and activated glucose-6-phosphate dehydrogenase and the malic enzyme, thus increasing hepatic glycogen amount, lowering blood glucose concentration and inhibiting the hepatic fatty acid β -oxidation in non-obese diabetic mice [ 75 , 76 ]. Genistein was found to increase the activities of catalase, superoxide dismutase, and glutathione peroxidase in livers of streptozotocin-induced diabetic rodents thus stimulating insulin sensitivity [ 77 , 78 ].…”

Section: The Role Of Isoflavones In Chronic Degenerative Diseasesmentioning

confidence: 99%

Pleiotropic Effects of Isoflavones in Inflammation and Chronic Degenerative Diseases

Bernatonienė

Kazlauskaitė

Kopustinskienė

2021

IJMS

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Isoflavones are phytoestrogens of plant origin, mostly found in the members of the Fabaceae family, that exert beneficial effects in various degenerative disorders. Having high similarity to 17-β-estradiol, isoflavones can bind estrogen receptors, scavenge reactive oxygen species, activate various cellular signal transduction pathways and modulate growth and transcription factors, activities of enzymes, cytokines, and genes regulating cell proliferation and apoptosis. Due to their pleiotropic activities isoflavones might be considered as a natural alternative for the treatment of estrogen decrease-related conditions during menopause. This review will focus on the effects of isoflavones on inflammation and chronic degenerative diseases including cancer, metabolic, cardiovascular, neurodegenerative diseases, rheumatoid arthritis and adverse postmenopausal symptoms.

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Section: The Role Of Isoflavones In Chronic Degenerative Diseasesmentioning

confidence: 99%

Pleiotropic Effects of Isoflavones in Inflammation and Chronic Degenerative Diseases

Bernatonienė

Kazlauskaitė

Kopustinskienė

2021

IJMS

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“…In addition, genistein can regulate the composition of the gut microbiota. For example, genistein treatment reduces the ratio of Firmicutes to Bacteroidetes and the relative abundance of Proteus , thus improving the inflammatory response and insulin resistance of T2D mice [ 150 ].…”

Section: Flavonoidsmentioning

confidence: 99%

Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications

Zhang

et al. 2021

IJMS

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Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance and inflammatory response. As enriched anti-inflammatory and antioxidant components in plants, natural polyphenols exhibit beneficial effects, including improving liver fat accumulation and dyslipidemia, reducing blood pressure. Hence, they are expected to be useful in the prevention and management of MetS. At present, epidemiological studies indicate a negative correlation between polyphenol intake and MetS incidence. In this review, we summarized and discussed the most promising natural polyphenols (including flavonoid and non-flavonoid drugs) in the precaution and treatment of MetS, including their anti-inflammatory and antioxidant properties, as well as their regulatory functions involved in glycolipid homeostasis.

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“…These results suggested that besides improving blood glucose levels, genistein may act on β cells to directly protect them and prevent type 2 diabetes. Another study conducted in mice with high-fat diet- and streptozotocin-induced type 2 diabetes, showed that genistein administration (20 and 40 mg/kg) for eight weeks [ 116 ] reduced hyperglycemia, hyperlipidemia, and the serum levels of pro-inflammatory factors. Furthermore, genistein improved liver dysfunction, suppressed pathological changes, reduced the expression of inflammation-related proteins, and blocked hepatocyte apoptosis.…”

Section: Effects Of Isoflavones On Metabolic Syndrome and Its Constituent Diseasesmentioning

confidence: 99%

Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome

Yamagata

Yamori

2021

Molecules

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Isoflavones are polyphenols primarily contained in soybean. As phytoestrogens, isoflavones exert beneficial effects on various chronic diseases. Metabolic syndrome increases the risk of death due to arteriosclerosis in individuals with various pathological conditions, including obesity, hypertension, hyperglycemia, and dyslipidemia. Although the health benefits of soybean-derived isoflavones are widely known, their beneficial effects on the pathogenesis of metabolic syndrome are incompletely understood. This review aims to describe the association between soybean-derived isoflavone intake and the risk of metabolic syndrome development. We reviewed studies on soy isoflavones, particularly daidzein and genistein, and metabolic syndrome, using PubMed, ScienceDirect, and Web of Science. We describe the pathological characteristics of metabolic syndrome, including those contributing to multiple pathological conditions. Furthermore, we summarize the effects of soybean-derived daidzein and genistein on metabolic syndrome reported in human epidemiological studies and experiments using in vitro and in vivo models. In particular, we emphasize the role of soy isoflavones in metabolic syndrome-induced cardiovascular diseases. In conclusion, this review focuses on the potential of soy isoflavones to prevent metabolic syndrome by influencing the onset of hypertension, hyperglycemia, dyslipidemia, and arteriosclerosis and discusses the anti-inflammatory effects of isoflavones.

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Genistein ameliorates inflammation and insulin resistance through mediation of gut microbiota composition in type 2 diabetic mice

Cited by 54 publications

References 45 publications

Pleiotropic Effects of Isoflavones in Inflammation and Chronic Degenerative Diseases

Pleiotropic Effects of Isoflavones in Inflammation and Chronic Degenerative Diseases

Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications

Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome

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