Genistein alleviates the development of nonalcoholic steatohepatitis in <i><scp>A</scp>po<scp>E</scp><sup>―/―</sup></i> mice fed a high‐fat diet

Jeon, Sookyoung; Park, Youn‐Jin; Kwon, Young Hye

doi:10.1002/mnfr.201300112

Cited by 49 publications

(57 citation statements)

References 45 publications

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“…In addition, when administered within the diet, genistein can lower protein levels of CD36 and improve blood lipid levels and the degree of nonalcoholic fatty liver in ApoE-/-rats [27]. As expected, by using oil red O staining and cholesterol ester determinations, we demonstrated ( Figure 1) that genistein (10 or 50µmol/L) and herbimycin A suppressed intracellular lipid accumulation in SMCs, while daidzein had no effect.…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 53%

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Genistein suppresses smooth muscle cell-derived foam cell formation through tyrosine kinase pathway

Lin

Zhao

et al. 2015

Biochemical and Biophysical Research Communications

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 53%

“…In addition, genistein can lower protein levels of CD36 and improve blood lipid levels and the degree of non-alcoholic fatty liver in ApoE-/-rats [27]. However, limited research of genistein has been directed at examining its role in inhibiting the formation of SMC-derived foam cells.…”

Section: Studies From Epidemiological Investigations Have Indicated Tmentioning

confidence: 98%

Genistein suppresses smooth muscle cell-derived foam cell formation through tyrosine kinase pathway

Lin

Zhao

et al. 2015

Biochemical and Biophysical Research Communications

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“…Genistein, one of the major isoflavones in soybeans, has antioxidant and phytoestrogenic activities that may contribute to its potential anti-inflammatory, anticarcinogenic, and hypocholesterolemic effects [18,19]. We have previously reported that genistein alleviated NASH as well as hypercholesterolemia and obesity in ApoE −/− mice fed a high-fat diet (HFD), suggesting that restoration of altered cholesterol metabolism and inhibition of oxidative stress and inflammation may be involved in the protective effect of genistein against NASH development [18].…”

Section: Introductionmentioning

confidence: 99%

“…We have previously reported that genistein alleviated NASH as well as hypercholesterolemia and obesity in ApoE −/− mice fed a high-fat diet (HFD), suggesting that restoration of altered cholesterol metabolism and inhibition of oxidative stress and inflammation may be involved in the protective effect of genistein against NASH development [18]. We also observed the inhibitory effect of isoflavones against endoplasmic reticulum (ER) stress-induced cell death and tau hyperphosphorylation in neuroblastoma cells [20,21].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Genistein against Neuronal Degeneration in ApoE−/− Mice Fed a High-Fat Diet

Park

Jeon

et al. 2016

Nutrients

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Altered cholesterol metabolism is believed to play a causal role in major pathophysiological changes in neurodegeneration. Several studies have demonstrated that the absence of apolipoprotein E (ApoE), a predominant apolipoprotein in the brain, leads to an increased susceptibility to neurodegeneration. Previously, we observed that genistein, a soy isoflavone, significantly alleviated apoptosis and tau hyperphosphorylation in SH-SY5Y cells. Therefore, we investigated the neuroprotective effects of dietary genistein supplementation (0.5 g/kg diet) in the cortex and hippocampus of wild-type C57BL/6 (WT) and ApoE knockout (ApoE−/−) mice fed a high-fat diet (HFD) for 24 weeks. Genistein supplementation alleviated neuroinflammation and peripheral and brain insulin resistance. Reductions in oxidative and endoplasmic reticulum stress were also observed in ApoE−/− mice fed a genistein-supplemented diet. Beta-secretase 1 and presenilin 1 mRNA levels and beta-amyloid peptide (Aβ) protein levels were reduced in response to genistein supplementation in ApoE−/− mice but not in WT mice. Although the absence of ApoE did not increase tau hyperphosphorylation, genistein supplementation reduced tau hyperphosphorylation in both WT and ApoE−/− mice. Consistent with this result, we also observed that genistein alleviated activity of c-Jun N-terminal kinase and glycogen synthase kinase 3β, which are involved in tau hyperphosphorylation. Taken together, these results demonstrate that genistein alleviated neuroinflammation, Aβ deposition, and hyperphosphorylation in ApoE−/− mice fed an HFD.

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“…Unstressed ( n = 14) and SCUMS ( n = 14) hamsters, of which unstressed ( n = 7) and stressed ( n = 7) animals were fed daily with genistein-enriched chow (500 mg/kg diet) [18] for 14 days with respect to their corresponding controls ( n = 14) fed with normal chow, were evaluated. The SCUMS group was exposed to the following stressful conditions for 14 days: light/dark cycle inverted, deprivation of water, inclination of cage, empty bottle, and wet litter.…”

Section: Methodsmentioning

confidence: 99%

Genistein Modifies Hamster Behavior and Expression of Inflammatory Factors following Subchronic Unpredictable Mild Stress

et al. 2018

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Background: Previous studies have pointed to the protective role of genistein against stress adaptations although neuromolecular mechanisms are not yet fully known. With this work, we evaluated the influence of such a phytoestrogen on hamster behavioral and molecular activities following exposure to subchronic unpredictable mild stress. Methods: The motor behaviors of hamsters (n = 28) were analyzed using elevated plus maze (EPM) test, hole board (HB) test, and forced swim test (FST). In addition, neurodegeneration events were assessed with amino cupric silver stain, while expression variations of tropomyosin receptor kinase B (TrkB), nuclear factor kappa-B1 (NF-κB1), and heat shock protein 70 (Hsp70) mRNAs were highlighted in limbic neuronal fields via in situ hybridization. Results: Genistein accounted for increased motor performances in EPM and HB tests but reduced immobility during FST, which were correlated with diminished argyrophilic signals in some limbic neuronal fields. Contextually, upregulated Hsp70 and TrkB mRNAs occurred in hippocampal (HIP) and hypothalamic neuronal fields. Conversely, diminished NF-κB1 levels were mainly obtained in HIP. Conclusion: Hormonal neuroprotective properties of genistein corroborating anxiolytic and antidepressant role(s) through elevated expression levels of stress proteins and trophic factors may constitute novel therapeutic measures against emotional and stress-related motor performances.

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Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE^―/― mice fed a high‐fat diet

Abstract: GEN alleviated NASH as well as hypercholesterolemia and obesity in ApoE(-/-) mice fed an HFD. Restoration of altered cholesterol metabolism and oxidative stress may be involved in the protective effect of GEN against NASH development.

Cited by 49 publications

References 45 publications

Genistein suppresses smooth muscle cell-derived foam cell formation through tyrosine kinase pathway

Genistein suppresses smooth muscle cell-derived foam cell formation through tyrosine kinase pathway

Protective Effect of Genistein against Neuronal Degeneration in ApoE−/− Mice Fed a High-Fat Diet

Genistein Modifies Hamster Behavior and Expression of Inflammatory Factors following Subchronic Unpredictable Mild Stress

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Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE―/― mice fed a high‐fat diet

Abstract: GEN alleviated NASH as well as hypercholesterolemia and obesity in ApoE(-/-) mice fed an HFD. Restoration of altered cholesterol metabolism and oxidative stress may be involved in the protective effect of GEN against NASH development.

Cited by 49 publications

References 45 publications

Genistein suppresses smooth muscle cell-derived foam cell formation through tyrosine kinase pathway

Genistein suppresses smooth muscle cell-derived foam cell formation through tyrosine kinase pathway

Protective Effect of Genistein against Neuronal Degeneration in ApoE−/− Mice Fed a High-Fat Diet

Genistein Modifies Hamster Behavior and Expression of Inflammatory Factors following Subchronic Unpredictable Mild Stress

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Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE^―/― mice fed a high‐fat diet