Genistein: A promising therapeutic agent for obesity and diabetes treatment

Behloul, Nouredine; Wu, Guanzhong

doi:10.1016/j.ejphar.2012.11.013

Cited by 173 publications

(113 citation statements)

References 69 publications

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“…The present results were similar to previous findings where feeding Long-Evans rats significantly reduced VAT weights when fed a High-Iso vs. a Low-Iso diet [20,29]. While genistein has been shown to have weight reducing and diabetic protecting properties [30], it is interesting to note that equol represents the major circulating isoflavonoid in the present study that has been shown to have beneficial weight and VAT reducing actions [19,31].…”

Section: Body Weight Gain and Vat Weightsupporting

confidence: 81%

Noble Rats Display Decreased Weight Gain and Visceral Adiposity via Lifelong Exposure to an Isoflavone-Rich Diet

Lephart¹

2014

J Nutr Health Food Sci

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Section: Body Weight Gain and Vat Weightsupporting

confidence: 81%

Noble Rats Display Decreased Weight Gain and Visceral Adiposity via Lifelong Exposure to an Isoflavone-Rich Diet

Lephart¹

2014

J Nutr Health Food Sci

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“…Numerous clinical trials indicate that regular consumption of isoflavone-rich foods may reduce the risk of breast and prostate cancers (Fritz et al 2013;Mourouti and Panagiotakos 2013;van Die et al 2014). Besides chemopreventive effects, major soybean isoflavones, genistein and daidzein, are considered promising agents for the treatment of diabetes, obesity and neurodegenerative diseases (Zhao et al 2009;Behloul and Wu 2013). The interest in isoflavones as potential therapeutic agents boosted research aimed at establishing biotechnological methods for their production, based chiefly on in vitro cultures of leguminous plants.…”

Section: Introductionmentioning

confidence: 99%

Plant growth regulators affect biosynthesis and accumulation profile of isoflavone phytoestrogens in high-productive in vitro cultures of Genista tinctoria

Łuczkiewicz

Kokotkiewicz

Głód

2014

Plant Cell Tiss Organ Cult

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The influence of plant growth regulators on biomass growth and the accumulation of medicinally-relevant isoflavone phytoestrogens, derivatives of genistein and daidzein (8 compounds including aglycones, glucosides and glucoside esters) in callus cultures of Genista tinctoria (Fabaceae) was examined. The experiments included 10 auxins [2,4-dichlorophenoxyacetic acid (2,4-D), p-chlorophenoxyacetic acid, indole-3-acetic acid, indole-3-butyric acid, indole-3-propionic acid, 1-naphthaleneacetic acid, b-naphthoxyacetic acid, picloram, 2,3,5-triiodobenzoic acid (TIBA), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)] and 7 cytokinins [6-benzylaminopurine, forchlorfenuron, 1,3-diphenylurea, 2-isopentenyladenine, kinetin (KIN), thidiazuron, zeatin] applied at 0.5 and 5.0 mg l Among the cytokinins tested, the highest isoflavone content (6,436.26 mg/100 g dry weight) and the fastest biomass growth (Gi = 892.46 %) were obtained for 0.5 mg l -1 KIN used jointly with 5.0 mg l -1 2,4-D. In the group of auxins, the combination of 0.5 mg l -1 TIBA and 5.0 mg l -1 KIN provided the fastest culture growth (Gi = 983.07 %) and the isoflavone concentration of 10,474.23 mg/100 g dry weight, which is so far the highest amount of these metabolites achieved in callus cultures of higher plants.

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“…Though the lake has been an unindustrialised area and basically pristine by edaphic background, apparently, unknown natural anti-estrogenic factors may be involved in the PJ sediment. It is common knowledge that plants are sources of estrogenic compounds, mainly belonging to chemical classes such as isoflavones (genistein, diadzein), lignans (pinoresinol) and coumestans (coumestrol), which may even have anti-estrogenic impact (Horn-Ross et al 2003), some even important pharmaceuticals in use today, like taxol (Adams et al 1993), resveratrol (Asensi et al 2002), genistein (Behloul and Wu 2013), among others (Usui 2006, Liu et al 2010. It may therefore be suggested that even clean sediments formed to a large extent from plant-origin material can have some potency of similar nature.…”

Section: Some Methodological Perspectives Of the Current Studymentioning

confidence: 99%

Probing the xeno-oestrogenic impact of sediment cores contaminated by the pulp and paper industry: induction of aromatase cyp19a1b in late larval zebrafish

Sahoo

Oikari

2014

J Soils Sediments

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To assess xenoestrogenicity, the 20 days-post-fertilization zebrafish (20dpfZF) life-stage was experimentally exposed to known model chemicals as well as to environmentally contaminated samples. From a selection of key responsive genes, molecular responses associated with the steroidogenic impact (brain aromatase, cyp19a1b and vitellogenin isoform 1, vtg1) were used to assess the endocrinic modulation by xenoestrogenic samples. This work showed diverse in vivo responses by the 20dpfZF, from pure chemicals (bisphenol A, BPA; 17 -ethinylestradiol, EE2; nonylphenol, NP; octylphenol, OP), and their mixture combinations, and to industrially contaminated sediment samples. Gene expression analysis of cyp19a1b and vtg1 in exposed 20dpfZF showed the estrogenic potencies of chemicals in the order: EE2 > OP > BPA > NP. Transcriptional up-regulation of vtg1 in early juvenile fish exposed to mixtures (BPA + NP + OP), relative to individual concentrations, suggest in minimum the additive in vivo effect of a mixture of very low sublethal doses of single xenoestrogens. Complementary expression of cyp19a1b and vtg1 in 20dpfZF, exposed to artificially-spiked sediment with EE2 established the estrogenresponsiveness of the model. In contrast, the lack of simple estrogenic or antiestrogenic trait of correspondence in biomarker transcription was evident from exposure to two types of industrially contaminated sediments, suggesting common non-linearity of in vivo response by the model. The results also highlight the applicability of 20dpfZF in the assessment of remediation and monitoring of historically polluted sites. This study showed that the 20dpfZF addressed the regulatory requirement of a multi-purpose and cost-effective ecotoxicological model capable of in vivo genomic assessment of endocrineactive substances in aquatic samples.

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Genistein: A promising therapeutic agent for obesity and diabetes treatment

Cited by 173 publications

References 69 publications

Noble Rats Display Decreased Weight Gain and Visceral Adiposity via Lifelong Exposure to an Isoflavone-Rich Diet

Noble Rats Display Decreased Weight Gain and Visceral Adiposity via Lifelong Exposure to an Isoflavone-Rich Diet

Plant growth regulators affect biosynthesis and accumulation profile of isoflavone phytoestrogens in high-productive in vitro cultures of Genista tinctoria

Probing the xeno-oestrogenic impact of sediment cores contaminated by the pulp and paper industry: induction of aromatase cyp19a1b in late larval zebrafish

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