Abstract:Background: NLRP3 inflammasome activation and pyroptosis play a significant role in myocardial ischemia reperfusion injury (MI/RI). Geniposide was reported to show potential therapeutic use for MI/RI with its anti-inflammatory and anti-oxidative properties. However, research on the specific mechanism of geniposide has not been reported.Methods: The Myocardial ischemia-reperfusion injury (MI/RI) model of animal was created in male C57BL/6J mice and the hypoxia reoxygenation model was established for the in vitr… Show more
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