Geniposide restricts angiogenesis in experimentary arthritis via inhibiting Dnmt1-mediated PTEN hypermethylation

Bu, Yanhong; Wu, Hong; Deng, Ran; Wang, Yan

doi:10.1016/j.intimp.2022.109087

Cited by 4 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gardeniae fructus (GF), prepared from the dried ripe fruit of Gardenia jasminoides J. Ellis, is widely used in traditional Chinese medicine and food supplements. Geniposide (GE) is the main component of GF and has various potential biological activities in the treatment of diabetes, liver injury, arthritis, and depression . However, GE has been reported to cause hepatotoxicity in both in vivo and in vitro studies. , According to published data, three consecutive days of 280 mg/kg or a single dose of 574 mg/kg GE resulted in hepatotoxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism

Zhao

Huang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Genipin (GP), the reactive metabolite of geniposide (GE), is responsible for GE-induced hepatotoxicity. As a potential detoxification pathway, the inactivation of GP by glutathione S-transferases (GSTs) has not yet been characterized. In this study, the thiol-GSH conjugates of GP, M532-1 and M532-2 were first identified and the catalytic activities of GSTs were investigated both in vitro and in vivo. GSTA1-1 and GSTA4-4 showed high activity in the formation of both thiol-GSH conjugates, whereas GSTA4-4 specifically catalyzed M532-2 formation in vitro. The active GST isoforms protect against alkylation of Nacetylcysteine (NAC), a classic model nucleophile. GST inhibition attenuated M532-1 formation in rat bile, confirming the in vivo catalytic role of GSTs. In conclusion, this study demonstrated the inactivation of GP by GSTs and implied that interindividual variability of GSTs may be a risk factor for susceptibility to GE-induced hepatotoxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism

Zhao

Huang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Geniposide has an anti-angiogenesis effect in vitro via decreased HUVEC migration, proliferation, and tubule formation. According to the mechanistic study, geniposide blocked the activation of the PI3K-Akt signalling pathway, upregulated the expression of PTEN and indirectly inhibited angiogenesis (Bu et al, 2022b;a). In experimental arthritis, geniposide confirmed anti-angiogenesis actions by preventing Dnmt1-mediated hypermethylation of the PTEN gene (Bu et al, 2022b).…”

Section: Terpenoidsmentioning

confidence: 99%

“…According to the mechanistic study, geniposide blocked the activation of the PI3K-Akt signalling pathway, upregulated the expression of PTEN and indirectly inhibited angiogenesis (Bu et al, 2022b;a). In experimental arthritis, geniposide confirmed anti-angiogenesis actions by preventing Dnmt1-mediated hypermethylation of the PTEN gene (Bu et al, 2022b). Sun et al discovered that geniposide dose-dependently reduced inflammatory manifestation and synovial microvessel density (MVD) in AIA rats.…”

Section: Terpenoidsmentioning

confidence: 99%

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Gao,

Song,

Chen

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia and inflammation underlies joint destruction. Delaying or even blocking synovial angiogenesis has emerged as an important target of RA treatment. Natural medicines has a long history of treating RA, and numerous reports have suggested that natural medicines have a strong inhibitory activity on synovial angiogenesis, thereby improving the progression of RA. Natural medicines could regulate the following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs pathway, NF-κB pathway, PPARγ pathway, JAK2/STAT3 pathway, etc., thereby inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, and total glucoside of Paeonia lactiflora Pall. Are currently the most representative of all natural products worthy of development and utilization. In this paper, the main factors affecting angiogenesis were discussed and different types of natural medicines that inhibit angiogenesis were systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming to provide new perspective and options for the management of RA by targeting angiogenesis.

show abstract

Geniposide alleviates imiquimod-induced psoriasis-like skin lesions in mice via inhibition of angiogenesis

Chen,

Liu,

Yin

et al. 2024

International Immunopharmacology

View full text Add to dashboard Cite

Geniposide restricts angiogenesis in experimentary arthritis via inhibiting Dnmt1-mediated PTEN hypermethylation

Cited by 4 publications

References 39 publications

Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism

Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Geniposide alleviates imiquimod-induced psoriasis-like skin lesions in mice via inhibition of angiogenesis

Contact Info

Product

Resources

About